Latest Articles

From polygenic risk to functional genomics: a framework for precision gynecological disease modeling.

Gynecological conditions including endometriosis, polyendocrine metabolic ovarian syndrome and malignancies cause widespread chronic morbidity and infertility, yet translating genetic discoveries into biological mechanisms remains challenging. We propose a framework integrating …

Lack of socio-demographic participant diversity in endometriosis evidence risks unrepresentative clinical guidance: a structured review of a NICE guideline.

Petal-like g-C3N4-enabled electrochemical immunosensor for urinary cytokeratin 19 assessment in endometriosis: a proof-of-concept pilot study.

Endometriosis is a debilitating, estrogen-dependent gynecological disorder characterized by profound diagnostic delays due to clinical reliance on invasive laparoscopy. Developing noninvasive, point-of-care biomarker assessment remains a critical yet unmet medical …

Müllerian clear cell carcinoma arising from sigmoid endometriosis with pericolic lymph node metastasis in the absence of adnexal disease: a case report.

Malignant transformation of endometriosis is rare and most commonly involves the ovary. Extraovarian transformation, particularly in the gastrointestinal tract, is exceptional, and clear cell carcinoma (CCC) arising from intestinal endometriosis …

Distinct Systemic Inflammatory Signatures in Women with Endometriosis and Infertility Without Endometriosis: Implications for Assisted Reproduction.

Background and Objectives: Endometriosis is a chronic inflammatory disease associated with impaired fertility, but the extent to which its systemic inflammatory profile differs from that observed in infertile women without …

Shaofu Zhuyu decoction can inhibit the progression of endometriosis fibrosis through the transforming growth factor-β1/ smads signaling pathway mediated by 5' adenosine monophosphate-activated protein kinase.

To investigate the mechanisms by which Shaofu Zhuyu decoction (SFZYD, ) modulates fibrosis in a mouse model of endometriosis.

The Phendo Project: How FemTech Is Advancing Endometriosis Research and Women's Health.

FemTech continues to evolve and advance despite persistent research and funding gaps. In this News and Perspectives article, JMIR Correspondent Jenny Castillo Cato reports on an innovative, cross-disciplinary research project …

Machine learning-integrated molecular subtyping reveals two biologically distinct endometriosis subtypes in the EndometDB database.

Endometriosis affects approximately 10% of reproductive-age women, with a diagnostic delay of 7-10 years. Despite clinical heterogeneity, current rASRM staging poorly predicts treatment outcomes. Molecular subtyping may reveal biologically meaningful …

Single-stapled versus double-stapled colorectal anastomosis after anterior resection: Systematic review and meta-analysis of short-term and functional outcomes.

The double-stapled anastomosis technique is widely considered the standard approach for colorectal anastomosis after anterior rectal resection. Recently, the single-stapled anastomosis technique has gained attention because it may reduce potential …

Transcriptome differences in lesions by color, and cancer mutations in endometriosis.

Endometriosis is a disease where cells similar to those of the uterine lining grow outside of the uterus, embedding into tissues and organs in the abdominal cavity, forming lesions and …