Earlier examinations of how risk factors relate to endometriosis (EMT) have largely depended on observational designs, which arrived at conflicting conclusions. The present approach seeks to probe the causal association …
Patient-reported outcome measures (PROMs) capture patients' experiences and perspectives of symptoms. One approach involves measuring the "most bothersome symptom," an outcome recommended in some regulatory guidance and core outcome sets. …
The meiotic spindle is essential for accurate chromosome segregation during oocyte maturation and fertilization, and its alteration might be considered a major contributor to age-related aneuploidy and reproductive failure. Spindle …
Endometriosis is a chronic, estrogen-dependent inflammatory disease that, despite its benign histology, displays several cancer-relevant features, including clonal expansion, somatic alteration-associated lesion evolution, tissue invasion, apoptosis resistance, immune evasion, angiogenesis, …
Endometriosis is a chronic inflammatory disorder affecting 5-10% of women of reproductive age and is associated with chronic pain and infertility. While research has mainly focused on local lesions, systemic …
Ovarian cancer remains one of the deadliest gynecologic malignancies because of late-stage diagnosis, biological heterogeneity, and the lack of effective early detection strategies. Epithelial ovarian cancer (EOC) comprises several histotypes, …
Endometriosis affects approximately 10% of reproductive-age women worldwide, with symptom burden significantly impacting quality of life. While current treatment guidelines focus primarily on hormonal and surgical interventions, the role of …
While negative neonatal outcomes are more frequent in fetuses with estimated fetal weight (EFW) < 10%, they also occur often in fetuses with appropriate-for-gestational-age. This study aimed to evaluate the …
Endometriosis is associated with immune dysregulation yet circulating cytokine measurements have shown limited discriminatory value. We investigated whether peripheral blood mononuclear cells (PBMCs) from women with endometriosis exhibit altered basal …
Background: Endometriosis affects 190 million women worldwide, so there is a need for accessible and more comprehensive knowledge regarding the pharmacotherapeutic options that can be offered to patients. This systematic …