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The causal role of gastroesophageal reflux disease in endometriosis: a bidirectional Mendelian randomization study.

Observational studies have reported an association between gastroesophageal reflux disease (GERD) and endometriosis. We conducted a two-sample and bidirectional Mendelian randomization analysis to determine whether those associations are causal. Two-sample …

Published: Oct. 30, 2024, midnight
Causality of immune cells and endometriosis: a bidirectional mendelian randomization study.

Endometriosis, a prevalent chronic condition, afflicts approximately 10% of women in their reproductive years. Emerging evidence implicates immune cells in the pathogenesis of endometriosis, particularly in angiogenesis, tissue proliferation, and …

Published: Oct. 26, 2024, midnight
Cross-Tissue Regulatory Network Analyses Reveal Novel Susceptibility Genes and Potential Mechanisms for Endometriosis.

Endometriosis (EMT) is a common gynecological disease with a strong genetic component, while its precise etiology remains elusive. This study aims to integrate transcriptome-wide association study (TWAS), Mendelian randomization (MR), …

Published: Oct. 26, 2024, midnight
Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.

Chronic pelvic pain (CPP) in women with no obvious pelvic pathology has few evidence-based treatment options. Our recent multicenter randomized controlled trial (GaPP2) in women with CPP and no obvious …

Published: July 15, 2024, midnight
Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study - Nature.com

Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study Nature.com

Published: July 9, 2024, 7 a.m.
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