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Phenotypic heterogeneity in adenomyosis: internal and external subtypes.

To investigate and compare the clinical characteristics and risk factors between intrinsic and extrinsic adenomyosis (AM), as well as the differences in their perioperative management and findings in the two …

Published: Aug. 31, 2025, midnight
Shaofu Zhuyu Decoction for Treating Endometriosis: A Systematic Review and Meta-Analysis.

Introduction: Shaofu Zhuyu Decoction (SZD) is a traditional Chinese herbal formula commonly used for gynecological disorders involving "blood stasis" and lower abdominal pain. Although applied clinically for endometriosis, evidence regarding …

Published: Aug. 29, 2025, midnight
Anatomic subtype-specific causal effects of endometriosis on ovarian cancer: a two-sample Mendelian randomization study.

While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = …

Published: Aug. 13, 2025, midnight
TET3 is a common epigenetic immunomodulator of pathogenic macrophages.

Through a combination of single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by TET3 overexpression (Toe-Macs) in three major human diseases associated …

Published: Aug. 12, 2025, midnight
Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors.

Globally, endometriosis affects almost 10% of reproductive-aged women, leading to chronic pain and discomfort. Endocrine-disrupting compounds (EDCs) seem to play a pivotal role as a causal factor. The current manuscript …

Published: Aug. 6, 2025, midnight
Comorbidity analysis and clustering of endometriosis patients using electronic health records.

Endometriosis is a prevalent, complex, inflammatory condition associated with a diverse range of symptoms and comorbidities. Despite its substantial burden on patients, population-level studies that explore its comorbid patterns and …

Published: July 31, 2025, midnight
Non-Hormonal Strategies in Endometriosis: Targets with Future Clinical Potential.

Endometriosis is a chronic gynecological pathology marked by the aberrant proliferation of tissue analogous to the endometrial lining outside the uterine cavity. This disorder frequently engenders persistent pelvic discomfort, infertility, …

Published: July 17, 2025, midnight
miRNA in Endometriosis-A New Hope or an Illusion?

Background: Endometriosis is a complex, estrogen-dependent condition that can significantly impact women's quality of life and fertility. Current diagnostic strategies remain invasive and often prolonged, demonstrating the need for reliable, …

Published: July 8, 2025, midnight
Impact of non-medical treatments of endometrioma on pregnancy outcome: a systematic review and meta-analysis.

This meta-analysis assesses the impact of non-medical endometrioma treatments on pregnancy rates in infertile women with endometriosis. Based on a search of PubMed, Scopus, EMBASE and Web of Science, 24 …

Published: May 8, 2025, midnight
Pilot Clinical and Radiomic Analysis of Deep Infiltrating Endometriosis of the Parametrium Using Shannon Entropy: A Retrospective Cohort Study.

Ultrasound techniques for diagnosing deep infiltrating endometriosis (DIE) currently lack a quantitative method to assess microstructural heterogeneity in relation to diagnosis and clinical symptoms. This study evaluates Shannon entropy-based radiomics …

Published: April 11, 2025, midnight
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