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Why does surgery for endometriosis-associated infertility often fail to improve pregnancy outcome?

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …

Published: March 5, 2026, midnight
CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis.

Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP in endometriosis.

Published: March 5, 2026, midnight
Bladder Endometriosis as Part of Complex Pelvic Deep Endometriosis: Surgical Challenges and Outcomes in a Reference Center.

Objective: To analyze multiple aspects of advanced bladder endometriosis surgery, based on the experience of an endometriosis reference center. Methods: This retrospective/prospective study included 80 consecutive patients with deep bladder …

Published: March 5, 2026, midnight
Omega-3 polyunsaturated fatty acid intake and pain, inflammatory cytokines, and quality of life in endometriosis.

Endometriosis is a chronic inflammatory gynecologic disorder associated with pelvic pain and impaired health-related quality of life (HRQoL). Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory potential and may confer adjunctive …

Published: March 4, 2026, midnight
High prevalence of endometriosis in women with chronic pelvic pain and confirmed pelvic varicosities: a multiparametric MRI study.

Chronic Pelvic Pain (CPP) presents significant diagnostic challenges, often involving multiple pathologies, including endometriosis and pelvic venous disorders. This study examined the prevalence of endometriosis among women with confirmed pelvic …

Published: March 3, 2026, midnight
Female infertility - risk factors.

Female infertility is a complex health concern with a multitude of risk factors and aetiologies. This current narrative review was planned to highlight the various significant contributors to female infertility, …

Published: Feb. 26, 2026, midnight
Sexual Quality of Life after vNOTES surgery: a systematic literature review.

To systematically review the literature on women's sexual quality of life after Transvaginal Natural Orifice Endoscopic Surgery (vNOTES) for gynecological and non-gynecological procedures, and to assess women's perceptions of vNOTES, …

Published: Feb. 26, 2026, midnight
An Overview of Endometriosis and Potential Pharmacogenetic Targets.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects approximately 10-15% of women of reproductive age globally and is characterized …

Published: Feb. 25, 2026, midnight
Endometriosis pain index: development of a model to predict poor pain-related quality of life after endometriosis surgery through machine learning analysis of registry data.

Predictive tools are lacking for pain-related outcomes after endometriosis surgery. The objective of this study was to develop and validate a machine learning-based clinical model to predict poor pain-related quality …

Published: Feb. 25, 2026, midnight
Ovarian Sclerosing Stromal Tumor. Spectrum of Ultrasound Findings. A Case Report and Review of Literature.

We present a case of a very rare benign ovarian tumor, a sclerosing stromal tumor (SST). In addition, we performed a review of the literature to describe the spectrum of …

Published: Feb. 25, 2026, midnight
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