This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian …
Endometriosis is an estrogen-dependent disorder with unclear molecular mechanisms. Ferroptosis, a regulated iron-dependent cell death, may play a key role, yet the specific genes involved remain underexplored.
Endometriosis is a common chronic gynecological condition that affects approximately 10% of women of reproductive age worldwide.
While epidemiological studies have associated endometriosis with ovarian cancer risk, the causal relationships across anatomic subtypes and histotypes remain undefined. Using two-sample Mendelian randomization with 84 genetic instruments (F-statistic = …
To assess the potential impact of years of education, which serves as a measure of socioeconomic inequality, on the occurrence of endometriosis, and to quantify the potential influence of modifiable …
New therapeutic targets for endometriosis predicted through Mendelian randomization analysis and case-control trials Frontiers
Endometriosis has been linked to several systemic complications, including cardiovascular disease (CVD), atrial fibrillation (AF), heart failure (HF), hypertension, stroke, and ischemic stroke. The potential causal relationship between endometriosis and …
Background: Dysmenorrhea is a common gynecological symptom among reproductive-aged women, associated with substantial pain and decreased quality of life. Previous studies have suggested that inflammatory and hormonal fluctuations linked to …
Dietary factors and risk for endometriosis: a Mendelian randomization analysis Nutrition & Metabolism