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Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine.

Ferroptosis is a potential target for the treatment of endometriosis (EMs). The role of andrographolide (AP) in the ferroptosis has gradually attracted attention, but its mechanism of action in endometriosis …

Published: Dec. 18, 2025, midnight
Coexistence of endometriosis and inflammatory bowel disease: a case series and practical diagnostic review.

The objective of this review is to identify key clinical lessons and highlight diagnostic and therapeutic strategies derived from case reports and recent literature. Particular attention is given to recognising …

Published: Dec. 18, 2025, midnight
Endometriosis Surgery: Debates About Restorative Reproductive Medicine.

For many patients with endometriosis, laparoscopic surgery is the most effective treatment to alleviate severe chronic pelvic pain and improve quality of life. Because endometriosis is common among individuals with …

Published: Dec. 18, 2025, midnight
Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies.

Endometriosis, which affects approximately 10% of women of reproductive age, is a complex inflammatory disease with significant immune system disturbances caused by an inadequate immune response to retrograde menstruation and …

Published: Dec. 18, 2025, midnight
APOL1-mediated kidney disease: a narrative review of the lessons learnt from the past 15 years.

Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African …

Published: Dec. 17, 2025, midnight
Borderline ovarian clear cell tumor arising from endometriosis during long-term dienogest therapy: a case report.

Endometriomas, commonly known as ovarian chocolate cysts, are a prevalent condition in women of reproductive age. They are cysts formed by the ectopic growth of endometrial tissue within the ovary, …

Published: Dec. 17, 2025, midnight
Visualizing pain disparities: Using graphic medicine to promote resistance to medical ableism.

This research investigates the potential for graphic medicine to foster resistance to medical ableism among those with feminized pain (i.e., endometriosis). We unite community and health psychology and disability studies …

Published: Dec. 16, 2025, midnight
Is surgery for endometriomas ever indicated?

Endometriomas can be managed through various approaches, including careful observation, medical suppressive therapy, or surgical intervention. Malignancy is rarely a concern in women of reproductive age, making pain relief and …

Published: Dec. 15, 2025, midnight
Burrowing behavior is a potential non-invasive proxy for lesion development in a syngeneic murine model of endometriosis.

Endometriosis (EM) is a persistent, chronic inflammatory condition associated with excruciating pelvic pain and infertility. The absence of a pre-clinical model that reliably replicates the clinical and functional hallmarks of …

Published: Dec. 12, 2025, midnight
Microvascular hypoxia and inflammation in chronic pain syndromes.

In this opinion, we propose that compromised microvascular perfusion and inflammation are fundamental drivers of chronic pain syndromes, with many of these conditions sharing a common etiology involving suboptimal blood …

Published: Dec. 8, 2025, midnight
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