Latest Articles

Menstrual Effluent in the Pathogenesis and Diagnosis of Endometriosis-A Systematic Review.

Background: The individual and social burden of endometriosis is high, and the diagnosis is usually delayed by 7-10 years. Menstrual effluent (ME) represents an accessible and uniquely informative biofluid. This …

An Overview of Endometriosis and Potential Pharmacogenetic Targets.

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity. It affects approximately 10-15% of women of reproductive age globally and is characterized …

Development of a novel meta-polygenic risk score for risk assessment and clinical manifestation prediction in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease with multifactorial pathogenesis. Although polygenic risk scores (PRSs) have been developed to enable early prediction, their accuracy remains limited. To …

Ovarian Sclerosing Stromal Tumor. Spectrum of Ultrasound Findings. A Case Report and Review of Literature.

We present a case of a very rare benign ovarian tumor, a sclerosing stromal tumor (SST). In addition, we performed a review of the literature to describe the spectrum of …

Systems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation.

Female reproductive disorders represent a major global health challenge. Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix …

MLH1 rs63749795 variant confers increased risk for endometriosis: a genetic association study.

The present study aimed to investigate the association between two MutL homolog 1 (MLH1) single-nucleotide polymorphisms (SNPs), rs63749795 and rs63749820, and the risk of endometriosis.

Rare variant analyses provide insights into the genetic architecture of endometriosis.

What is the Evidence on Lifestyle Interventions for the Symptom Management of Pelvic Pain in Women With Endometriosis or Adenomyosis? A Scoping Review.

Endometriosis and adenomyosis are chronic, debilitating, inflammatory conditions affecting women of reproductive age. Current management primarily focuses on pharmacologic therapies and surgical interventions; however, many individuals adopt self-directed lifestyle modifications …

The role of gut microbiota in modulating estrogen in the inflammatory milieu of endometriosis: A molecular and pathophysiological perspective.

Endometriosis is a prevalent estrogen-dependent chronic inflammatory condition that affects millions of women of reproductive age worldwide. It is characterized by the growth of endometrial tissue outside the uterine cavity, …

Global variability in the clinical presentation of endometriosis: A scoping review.

Endometriosis affects approximately 10-15 percent of women of reproductive age, yet its clinical presentation remains inconsistently reported. This scoping review mapped the global spectrum of endometriosis-related symptoms and examined factors …