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Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies.

Endometriosis, which affects approximately 10% of women of reproductive age, is a complex inflammatory disease with significant immune system disturbances caused by an inadequate immune response to retrograde menstruation and …

Published: Dec. 18, 2025, midnight
Pharmacophoric Investigation of a Natural Product-like Class of Aromatase Inhibitors Using Molecular Modeling.

Endometriosis is a condition affecting approximately 10% of reproductive-age women in which endometrial tissue is found in locations outside the uterus, often causing debilitating symptoms. Aromatase, an enzyme that also …

Published: Dec. 18, 2025, midnight
APOL1-mediated kidney disease: a narrative review of the lessons learnt from the past 15 years.

Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African …

Published: Dec. 17, 2025, midnight
Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis.

Peritoneal endometriosis causes pelvic pain and infertility, but the underlying mechanisms related to these symptoms are not fully understood. Endometriosis diagnosis is typically delayed; thus, patient samples are unsuitable to …

Published: Dec. 15, 2025, midnight
Posterior Deep Infiltrating Endometriosis Surgery: current status and mapping of care in France.

Endometriosis is a frequent pathology affecting approximately 10% of the general population. Its diagnosis and management have improved in recent years. In France, a national strategy against endometriosis has been …

Published: Dec. 15, 2025, midnight
Delayed onset of HPV-associated uterine malignancies: seven pathogenetic factors in contrast to cervical cancer.

Human papillomavirus (HPV) is a well-established etiological agent for cervical cancer, yet its contribution to endometrial malignancies remains underrecognized and mechanistically distinct. This paper synthesizes current evidence to explain the …

Published: Dec. 13, 2025, midnight
Non-Invasive Methods for Early Diagnosis of Endometriosis-A Comprehensive Narrative Literature Review.

Endometriosis is a common gynecological pathology, with an incidence of nearly 10% in patients of reproductive age, and is still underdiagnosed. A thorough and well-spread diagnostic study of endometriosis based …

Published: Dec. 13, 2025, midnight
Burrowing behavior is a potential non-invasive proxy for lesion development in a syngeneic murine model of endometriosis.

Endometriosis (EM) is a persistent, chronic inflammatory condition associated with excruciating pelvic pain and infertility. The absence of a pre-clinical model that reliably replicates the clinical and functional hallmarks of …

Published: Dec. 12, 2025, midnight
Progestins - a review of clinical application in gynecology.

Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone …

Published: Dec. 12, 2025, midnight
Coexistence of gynecological pathology with endometriosis and adenomyosis.

Both endometriosis and adenomyosis can impact quality of life. Endometriosis is a chronic, benign, condition characterized by the growth of endometrium outside the uterus, which affects ~10% of women from …

Published: Dec. 12, 2025, midnight
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