Endometriosis is a chronic, inflammatory, and multifactorial disease characterized by the presence of endometrial tissue outside the uterine cavity, often associated with debilitating symptoms. It affects approximately 10% of women …
Endometriosis involves oestrogen-dependent chronic inflammation and the abnormal proliferation of ectopic endometrial tissue. Conventional hormonal therapies suppress systemic oestrogen, but do not fully address local oxidative and inflammatory signalling. This …
Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …
The NOD-like receptor family containing pyridine domain 3 (NLRP3) inflammasome serves as a pivotal mediator of innate immune responses and a central driver of inflammatory processes. Upon detection of pathogenic …
Oxidative stress plays a central role in reproductive disorders, with food bioactive compounds offering therapeutic potential through their antioxidant properties. This review examines antioxidant active ingredients from plant-based foods and …
Monocytes, as essential components of the immune system, play a pivotal role in regulating immune responses throughout the menstrual cycle. Their cytokine secretion is integral to immune modulation, influencing processes …
Many experimental and clinical studies published so far demonstrate that melatonin-produced mainly by the pineal gland located deep in the middle of the brain, between the two cerebral hemispheres, and …
The immune system is crucial in protecting against disease, but it can also contribute to chronic illnesses when it malfunctions, with different conditions involving either inflammation or immune suppression. Current …
Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial-like tissue outside the uterine cavity, often resulting in debilitating symptoms and significant impacts on quality of life. …
Ghrelin, a peptide composed of 28 amino acids, is recognized for its role in regulating appetite and energy balance. Recently, it has also been identified as an immunomodulator that could …