Latest Articles

Human Endometriotic Lesion-Derived Small Extracellular Vesicles Impair Macrophage Function in the Peritoneal Microenvironment.

Endometriosis (EM) is a chronic inflammatory disease that affects ∼10% of women during reproductive age. It is characterised by ectopic (ECT) growth of endometrial-like tissue mainly in the pelvic cavity. …

Behavioral attenuation of marble burying and digging mirrors evoked and non-evoked phenotypes in the endometriosis mouse model.

Endometriosis (ENDO) is an estrogen-dependent chronic gynaecological manifestation of uterine fragments attached outside of the uterus, accompanied by debilitating chronic pelvic pain. The evoked assays often employed fail to capture …

Association between the Modified Cardiometabolic Index and Endometriosis in an American Cohort: Insights from a Cross-sectional Analysis.

The modified cardiometabolic index (MCMI), an integrated measure of visceral fat and lipid metabolism, has been widely applied in metabolic disease research. However, its relationship with endometriosis has not been …

Integration of Raman tweezers and machine learning for label-free single-cell characterization of endometriosis cells.

Endometriosis occurs when endometrial tissue grows outside the uterus, affecting millions of women worldwide. Despite extensive research, its cellular mechanisms remain unclear, complicating both diagnosis and treatment. This study presents …

Three-Dimensional Modeling of Deep Endometriosis from Pelvic MRI: Feasibility, Clinical Perception, and Preliminary Prospective Evaluation.

To evaluate the feasibility of three-dimensional (3D) modeling of deep endometriosis (DE) from pelvic MRI, to assess its perceived usefulness by gynecologic surgeons, and to explore its transposability in clinical …

Risk factors and prediction models for pain after endometriosis-related surgery-what do we (not) know yet.

Soluble Mediators Related to Immunity in Pregnancy-Related Disorders: Roles of Immune Checkpoints, Platelet Activation Markers, TNF Receptors, and NETs.

Soluble immune mediators are key regulators of immune responses that help maintain self-tolerance and prevent autoimmunity. Recently, many forms of these mediators have been found, including soluble immune checkpoints, soluble …

Dydrogesterone and Letrozole Combination for the Treatment of Endometriosis: A Mechanism-Based Therapeutic Approach.

Endometriosis is a complex, estrogen-dependent disease with limited effective treatments that often focus on symptom management rather than addressing the underlying pathology. Current therapies, such as progestins and GnRH agonists, …

2-Deoxyglucose dendrimer-enabled niclosamide delivery to FRβ-expressing macrophages alleviates endometriosis progression and associated hyperalgesia.

Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We …

Dietary Caloric Restriction Suppresses Endometriosis by Inhibiting STAT3/ERK Pathways.

Endometriosis is a chronic, estrogen-dependent inflammatory condition that affects approximately 10% of reproductive-age women and is frequently associated with infertility and pelvic pain. Unlike many estrogen-dependent disorders, epidemiologic studies have …