Autoimmune hypothyroidism and endometriosis: evidence from bidirectional Mendelian randomization and an independent clinical cohort analysis.
Observational studies have reported comorbidity between autoimmune thyroid disease and endometriosis, but whether this reflects a direct causal relationship or shared susceptibility remains unclear. We evaluated the bidirectional relationship between …
Whole-body thermal therapies for symptom management and well-being in people assigned female at birth with chronic pelvic pain, dysmenorrhoea, endometriosis or adenomyosis: a scoping review protocol.
Dysmenorrhoea is one of the most frequent manifestations of chronic pelvic pain. Endometriosis and adenomyosis are among the most common pathological causes of secondary dysmenorrhoea. Symptoms often persist despite treatment, …
Low-energy extracorporeal shock wave therapy is associated with reduced inflammation and fibrosis in an E2-induced rat model of endometriosis and remains effective under menopause-mimicking conditions.
Endometriosis is an estrogen-dependent inflammatory disorder marked by ectopic lesions, chronic pelvic inflammation, and frequent recurrence. Extracorporeal shock wave therapy (ESWT) is a non-invasive modality with anti-inflammatory and regenerative potential, …
Investigation of the miRNA27a rs895819, miRNA222 rs2858060 and miRNA499a rs3746444 polymorphisms in Endometriosis.
The present study aimed to determine the allelic and genotypic frequencies of the miRNA27a rs895819, miRNA222 rs2858060 and miRNA499 rs3746444 polymorphisms and their possible association with endometriosis. This case-control study …
Identification and Validation of a Four-Gene Signature as a Novel Potential Diagnostic Biomarker Panel for Endometriosis: Causal and Mechanistic Insights from Mendelian Randomization and Bioinformatics.
Endometriosis (EMS) is an estrogen-dependent disease that can lead to chronic pain and infertility. Small ubiquitin-related modifier (SUMO)ylation, a key post-translational modification, has been demonstrated to be associated with endometrial …