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Pharmacophoric Investigation of a Natural Product-like Class of Aromatase Inhibitors Using Molecular Modeling.

Endometriosis is a condition affecting approximately 10% of reproductive-age women in which endometrial tissue is found in locations outside the uterus, often causing debilitating symptoms. Aromatase, an enzyme that also …

Published: Dec. 18, 2025, midnight
APOL1-mediated kidney disease: a narrative review of the lessons learnt from the past 15 years.

Fifteen years have elapsed since the publication of the seminal work establishing the association between risk variants in the Apolipoprotein L1 (APOL1) gene and kidney disease in individuals of African …

Published: Dec. 17, 2025, midnight
Case Report: Two clinical cases of severe deep infiltrating endometriosis with infertility-transplantation first or surgery first? Natural cycle or artificial cycle?

Deep infiltrating endometriosis (DIE) is a severe condition frequently linked to infertility, yet the optimal integration of surgery and assisted reproductive technology (ART) remains controversial. This study reports two cases …

Published: Dec. 16, 2025, midnight
Posterior Deep Infiltrating Endometriosis Surgery: current status and mapping of care in France.

Endometriosis is a frequent pathology affecting approximately 10% of the general population. Its diagnosis and management have improved in recent years. In France, a national strategy against endometriosis has been …

Published: Dec. 15, 2025, midnight
Is surgery for endometriomas ever indicated?

Endometriomas can be managed through various approaches, including careful observation, medical suppressive therapy, or surgical intervention. Malignancy is rarely a concern in women of reproductive age, making pain relief and …

Published: Dec. 15, 2025, midnight
Delayed onset of HPV-associated uterine malignancies: seven pathogenetic factors in contrast to cervical cancer.

Human papillomavirus (HPV) is a well-established etiological agent for cervical cancer, yet its contribution to endometrial malignancies remains underrecognized and mechanistically distinct. This paper synthesizes current evidence to explain the …

Published: Dec. 13, 2025, midnight
The interplay between migraine, endometriosis and polycystic ovarian syndrome: A systematic review.

BackgroundMigraine and gynecological conditions, such as endometriosis (EDM) and polycystic ovarian syndrome (PCOS), are highly prevalent among females and appear to influence each other, with a potential shared pathophysiological mechanism. …

Published: Dec. 12, 2025, midnight
Research trends in estrogen and rheumatoid arthritis: a systematic bibliometric approach.

Rheumatoid arthritis (RA) is a chronic autoimmune disease. An increasing body of evidence indicates that hormones, particularly estrogen, play a significant role in RA. To date, no bibliometric studies have …

Published: Dec. 12, 2025, midnight
Progestins - a review of clinical application in gynecology.

Progestins are a group of substances with a wide range of applications. They are classified into pregnanes, estranes, and gonanes, and further divided into four generations based on their testosterone …

Published: Dec. 12, 2025, midnight
Gender-Based Violence Among People With Disabilities: Qualitative Insights on Sexual and Reproductive Health Impacts Across the Life Course.

Women and gender-diverse people with disabilities are at an elevated risk of gender-based violence (GBV). This study examines how women and gender-diverse people with disabilities experience GBV and how such …

Published: Dec. 10, 2025, midnight
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