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Serum-derived small extracellular vesicles as biomarkers for predicting pregnancy and delivery on assisted reproductive technology in patients with endometriosis.

Endometriosis can cause of infertility, and evaluation methods for predicting clinical pregnancy outcomes are desired. Extracellular vesicles (EVs) exist in blood and it contains small non-coding RNAs (ncRNAs) that may …

Published: Jan. 17, 2025, midnight
Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis.

Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation …

Published: Dec. 25, 2024, midnight
Extracellular vesicles-derived MicroRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development.

Previous work indicated that the implantation and pregnancy rates of women with endometriosis are lower than those of healthy women during in-vitro fertilisation and embryonic transfer. And there are numerous …

Published: Dec. 23, 2024, midnight
MicroRNAs as Biomarkers and Therapeutic Targets in Female Infertility.

The study of microRNAs (miRNAs) has emerged in recent decades as a key approach to understanding the pathophysiology of many diseases, exploring their potential role as biomarkers, and testing their …

Published: Dec. 3, 2024, midnight
miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis.

Despite decades of research, the pathogenesis of endometriosis remains unclear. Recent studies have shown that microRNAs play an important role in this condition. In this study, we found that the …

Published: Nov. 28, 2024, midnight
Crosstalk Between Oxidative Stress and Epigenetics: Unveiling New Biomarkers in Human Infertility.

The correlation between epigenetic alterations and the pathophysiology of human infertility is progressively being elucidated with the discovery of an increasing number of target genes that exhibit altered expression patterns …

Published: Nov. 7, 2024, midnight
miR-193b-5p and miR-374b-5p Are Aberrantly Expressed in Endometriosis and Suppress Endometrial Cell Migration In Vitro.

(1) Background: Endometriosis is a highly prevalent gynecological disease affecting 10% of women of reproductive age worldwide. miRNAs may play a role in endometriosis, though their exact function remains unclear. …

Published: Nov. 3, 2024, midnight
The Relationship between The Expression of Sperm MicroRNA-149b and 34c and Sperm Quality in Men with Oligoasthenoteratozoospermia in Endometriosis.

The objective of this study was to investigate the correlation between the expression levels of sperm microRNA-149b and 34c and sperm quality in men diagnosed with oligoasthenoteratozoospermia.

Published: Oct. 30, 2024, midnight
Identification of Key miRNAs in Endometriosis.

Endometriosis, a prevalent gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, poses significant challenges in diagnosis and management due to its unclear pathogenesis and lack of …

Published: Oct. 25, 2024, midnight
Circulating Serum Micro-RNA as Non-Invasive Diagnostic Biomarkers of Endometriosis.

Endometriosis (END) is a painful gynecological condition. Clinical examination, imaging, and laparoscopy can provide a definitive diagnosis of END. Nonetheless, non-invasive biomarkers could help enhance and streamline the diagnostic process. …

Published: Oct. 19, 2024, midnight
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