Latest Articles

Modulating IL-11-dependent matrix stiffness to delay ovarian aging.

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. …

Obstructive anomalies without menses - partial distal vaginal agenesis.

Aspartame exposure promotes endometriosis progression through PTGS2-mediated oxidative stress and mitochondrial dysfunction.

Aspartame, a widely used artificial sweetener, has been implicated in multiple toxicities. However, its potential reproductive toxicity mechanisms remain unclear. This study aimed to investigate the underlying relationship between aspartame …

Endometriosis as a chronic endothelial disorder: thromboinflammation, vascular reprogramming, and systemic cardiovascular risk.

Microvascular thromboinflammation is a pervasive yet under-recognized driver of multisystem morbidity that links focal endothelial injury to distal organ dysfunction through interacting cellular and plasmatic networks. Contemporary paradigms remain fragmented: …

Single-nucleus analysis of menstrual fluid highlights gene expression differences in epithelial cells of endometriosis donors.

Endometriosis is a common complex gynecological condition that is difficult to efficiently diagnose and remains poorly understood. Menstrual fluid provides a non-invasive source of disease-relevant tissue and has been identified …

The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.

Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, plays a critical role in female reproductive health, particularly in ovarian function. This review provides …

Chemokine CCL21 promotes the pathological progression of endometriosis by regulating inflammatory cytokine expression and activating the NF-κB signaling pathway.

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various …

The opioid system in endometriosis: implications for endometrial receptivity and reproductive outcomes.

Endometriosis, a chronic inflammatory disease affecting 10-15% of women of reproductive age, remains a leading cause of female subfertility. While current management strategies focus on surgical excision and hormonal suppression, …

A Commentary on Dual Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands.

1,1-Bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) compounds in the presence or absence of a 4-hydroxylphenyl group bind both orphan nuclear receptor 4A1 (NR4A1) and NR4A2. In cancer cells, these compounds bind and inactivate pro-oncogenic …

Bladder endometriosis: a current overview of pathogenesis, diagnosis, and treatment approaches.

Endometriosis is a chronic inflammatory disease affecting approximately 10% of women of reproductive age. Urinary tract involvement is rare, occurring in approximately 1-2% of cases, with the bladder being the …