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Role of Transcription Factor, LIM Homeobox 9 (LHX9) in Inflammatory Response by PGE2 and Thrombin in SERPINA1-Silencing Endometrial Stromal Cells.

Endometriosis is hypothesized to result from retrograde menstruation where cell debris including endometrial stromal cells (ESCs) travel through the fallopian tubes. This chronic inflammatory disease is characterized by inflammatory and …

Published: Aug. 27, 2025, midnight
HOXC4 promotes proliferation of endometriotic stromal cells via the SLIT2-ROBO1 axis.

Current interventions for endometriosis mainly involve hormone therapies but have limited efficacy and unacceptable side effects due to the lack of selectivity to distinguish between endometriosis and endometrial tissues. Elucidating …

Published: Aug. 27, 2025, midnight
Spectrum of Histopathologic Findings in Transgender Men Undergoing Gender-Affirming Gynecologic Surgery Following Preoperative Androgen Therapy: A Tertiary Care Center Study.

IntroductionTransgender men are assigned female sex at birth, but identify with a masculine gender identity, prompting them to undergo gender-affirming surgery, usually following androgen therapy, which induces changes in histology …

Published: Aug. 26, 2025, midnight
How transcription factors regulate apoptosis in endometriosis (Review).

Endometriosis (EM) is a common chronic gynaecological disease that affects 10% of women of reproductive age globally. EM is defined as the presence of endometrial glands and stroma in extrauterine …

Published: Aug. 24, 2025, midnight
3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids.

The human endometrium is a dynamic tissue that lines the uterus and undergoes constant remodeling, making it especially susceptible to gynecological diseases like endometriosis and endometrial cancer. The molecular mechanisms …

Published: Aug. 23, 2025, midnight
Nuck canal cyst: use of immunohistochemistry to reveal vestigial endometriosis hidden within mural granulation tissue.

A case of a Nuck canal cyst (NCC) associated with vestigial endometriosis is presented. An ultrasound scan revealed a multicystic sac in the right groin of a 42-year-old woman who …

Published: Aug. 20, 2025, midnight
Polypoidal rectal endometriosis-a diagnostic dilemma.

Polypoidal rectal endometriosis is a rare and diagnostically challenging manifestation of deep infiltrating endometriosis that may mimic colorectal malignancy, especially in women lacking classical cyclical symptoms. We report such a …

Published: Aug. 13, 2025, midnight
Anti‑inflammatory and anti‑migratory properties of wild‑grape‑derived ε‑viniferin in human endometrial cells:  A potential therapy for endometriosis.

Endometriosis is a chronic gynecological disorder characterized by the ectopic growth and proliferation of endometrial tissue outside the uterine cavity, leading to inflammation. Although low‑dose contraceptive pills are widely used …

Published: Aug. 8, 2025, midnight
C57BL/6J mice best recapitulate fibrosis and inflammatory pathophysiology in syngeneic mouse model of endometriosis.

Endometriosis (ENDO), a chronic inflammatory disease affecting approximately 190 million women globally, is characterized by fibrosis, a feature often challenging to replicate in murine models. To identify an optimal syngeneic …

Published: Aug. 8, 2025, midnight
Cervical endometriosis mimicking cervical adenocarcinoma: A case report.

Cervical endometriosis is a rare benign condition characterized by ectopic endometrial glands and stroma within the cervix. Its clinical and imaging features resemble those of cervical adenocarcinoma, making preoperative diagnosis …

Published: Aug. 7, 2025, midnight
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