Deconvolution of DNA Methylation Data Reveals Cell-Type-Specific Epigenomic Signatures in Endometriosis and Eutopic Endometrium.
Endometriosis (EM) is a debilitating disease involving the growth of endometrial glands and stroma outside the uterus. To further our understanding of epigenomic dysregulation in EM and search for disease …
Endometriosis Then and Now: A 100-Year Journey Around Pathogenesis and Clinicopathologic Associations.
Nearly a century has passed since a seminal review article was published in 1928 in Archives of Pathology on ectopic endometriosis, presenting the dominant pathogenetic theories of the era: the …
Endometriosis phenotypes and staging in relation to lipid biomarkers: Findings from the ENDO Cohort Study.
Endometriosis has been linked to cardiometabolic alterations, but whether these associations vary by disease severity or phenotype is unclear. We examined lipid profiles across endometriosis diagnosis, stage, and typology.
From Gynecological Endocrine Disorders to Cardiovascular Risk: Insights from Rat Models.
Gynecological endocrine disorders, including polycystic ovary syndrome (PCOS), endometriosis as well as primary ovarian insufficiency (POI)/premature ovarian failure (POF), significantly impact women's reproductive health and overall well-being. While these conditions …
Beyond waste: menstrual blood as a powerful diagnostic tool for women's health.
Menstrual blood (MB), once thought of as nothing more than biological waste, has now come to be regarded as a noninvasive and low-cost diagnostic tool with great potential for women's …
Microvascular hypoxia and inflammation in chronic pain syndromes.
In this opinion, we propose that compromised microvascular perfusion and inflammation are fundamental drivers of chronic pain syndromes, with many of these conditions sharing a common etiology involving suboptimal blood …