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Adenomyosis and Adolescence: A Challenging Diagnosis and Complex Management.

Adenomyosis is a chronic, hormone-related disease characterized by the presence of the endometrial glands and stroma within the myometrium. This condition can manifest in various features, focal or diffuse adenomyosis …

Published: Oct. 22, 2024, midnight
The role and potential treatment of macrophages in patients with infertility and endometriosis.

Endometriosis is characterized as a macrophage-related ailment due to its strong link with immune dysfunction. Understanding the status of macrophage polarization in the context of endometriosis-related infertility is crucial for …

Published: Oct. 19, 2024, midnight
The long road of drug development for endometriosis - Pains, gains, and hopes.

Endometriosis, defined by the growth of endometrial tissues outside of the uterine cavity, is a global health burden for ~200 million women. Patients with endometriosis usually present with chronic pain …

Published: Oct. 18, 2024, midnight
Cost-effectiveness of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing device for treatment of heavy menstrual bleeding: a systematic review.

This study aims to provide a clear understanding of the relative economic evaluation of hysterectomy, first- and second-generation endometrial ablation, and levonorgestrel-releasing intrauterine device for treatment of heavy menstrual bleeding.

Published: Oct. 18, 2024, midnight
Eutopic and Ectopic Endometrial Interleukin-17 and Interleukin-17 Receptor Expression at the Endometrial-Myometrial Interface in Women with Adenomyosis: Possible Pathophysiology Implications.

Adenomyosis involves the infiltration of endometrial glands and stroma deep into the uterine tissue, causing disruption to the endometrial-myometrial interface (EMI). The role of interleukin-17 (IL-17) has been extensively studied …

Published: Oct. 17, 2024, midnight
Melanoma Cell Adhesion Molecule (CD 146) in Endometrial Physiology and Disorder.

The human endometrium, the innermost lining of the uterus, is the anatomic prerequisite for pregnancy. It is the only dynamic tissue that undergoes more than 400 cycles of regeneration throughout …

Published: Oct. 15, 2024, midnight
A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment.

To investigate if a positive result on ReceptivaDx for evaluation of B-cell lymphoma 6 (BCL6), a proposed marker of progesterone resistance associated with impaired uterine receptivity, correlates with a suboptimal …

Published: Oct. 15, 2024, midnight
Tissue specific regulation of transcription in endometrium and association with disease.

Are genetic effects on endometrial gene expression tissue specific and/or associated with reproductive traits and diseases?

Published: Oct. 14, 2024, 1:33 p.m.
Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway.

Ferroptosis is an iron-dependent programmed cell death process characterized by the accumulation of lethal oxidative damage. Localized iron overload is a unique clinical phenomenon in ovarian endometriosis (EM). However, the …

Published: Oct. 14, 2024, 1:25 p.m.
Exosomal miR-202 derived from leukorrhea as a potential biomarker for endometriosis.

Endometriosis (EMS) is a chronic gynecological disorder with an urgent need of a reliable non-invasive diagnostic strategy. Recently, there has been increasing interest in using the contents of exosomes, especially …

Published: Oct. 14, 2024, 1:25 p.m.
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