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Two Giant Cystic Uterine Adenomyomas in a Premenopausal Woman: The Largest Case to Date With Immunohistochemical Findings.

Cystic adenomyoma is a rare focal cystic variant of adenomyosis, and giant lesions are particularly uncommon. Malignant transformation has been reported in endometriosis-related disease, but the molecular features of cystic …

Published: Jan. 21, 2026, midnight
Umbilical Endometriosis Presenting as Cyclical Umbilical Bleeding: A Case Report.

Endometriosis is a benign, estrogen-dependent condition affecting 6%-10% of women of reproductive age, typically involving pelvic organs but occasionally presenting in extrapelvic locations such as the umbilicus. We report a …

Published: Jan. 21, 2026, midnight
The Reproductive Tract Microbiome and Female Fertility: Dysbiosis, Disease Links, and Emerging Therapeutic Strategies.

The reproductive tract microbiome plays a pivotal role in female fertility, with Lactobacillus-dominated communities maintaining a protective, low-pH environment. Dysbiosis-characterized by a reduction in Lactobacillus species and overgrowth of anaerobes-is …

Published: Jan. 21, 2026, midnight
Anything but Endo: Diagnostic Buck-Passing in Endometriosis Diagnosis.

People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, …

Published: Jan. 20, 2026, midnight
Noninvasive Imaging Diagnostics for Endometriosis.

Endometriosis is a prevalent gynecological condition affecting approximately 10% of women of reproductive age and up to 50% of those with infertility. It is characterized by the presence of endometrial-like …

Published: Jan. 20, 2026, midnight
Targeting endometrial stem cell in endometriosis treatment, a scoping review.

Endometriosis is characterized by the ectopic implantation of endometrial tissue affecting reproductive-aged women. Available therapies have still unmet needs namely due to recurrence rates and systemic side effects. Emerging evidence …

Published: Jan. 20, 2026, midnight
Hormonal treatment in endometriosis fails to prevent IL-6 increase and endometrium fibrosis but regulates levels of CYP17A, VEGF, and NFkB.

Endometriosis is a gynecological inflammatory disease characterized by the presence of ectopic endometrial-like tissue. This study aims to elucidate the effect of hormonal treatment in human endometriosis inflammation, angiogenesis and …

Published: Jan. 20, 2026, midnight
Mucin Biology as a Local Diagnostic and Promising Therapeutic Target in Endometriosis: Expression and Glycosylation Profiling.

Endometriosis (EM) is a chronic inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, yet its molecular mechanisms remain poorly understood. This study investigated the expression of …

Published: Jan. 20, 2026, midnight
The evolution of endometriosis research models: a paradigm shift from immortalized cell lines to organoids†.

Endometriosis is a complex condition affecting 10% of reproductive-age women worldwide, yet its study has long been hindered by the shortcomings of traditional research models. This review aims to propose …

Published: Jan. 19, 2026, midnight
Validation of the deep pelvis endometriosis index (dPEI) to evaluate surgical outcomes of robotic-assisted surgery for endometriosis.

The Deep Pelvic Endometriosis Index (dPEI) is a preoperative MRI-based score initially validated to predict surgical outcomes in patients undergoing laparoscopic treatment for deep pelvic endometriosis (DPE). Its applicability in …

Published: Jan. 19, 2026, midnight
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