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Integrative single-cell analysis reveals Bu-Shen-Huo-Xue Formula rescues iron-overloaded ovarian function via rewiring IFN-γ/JAK/STAT/CXCL10-driven immune-stromal interactions and BNIP3-mediated mitophagy in endometriosis.

Ovarian endometriosis (OE) is a leading cause of female infertility. Our previous work identified iron overload-driven oxidative stress and mitochondrial dysfunction in granulosa cells as key pathogenic features, yet the …

Published: May 23, 2026, midnight
Does Depression Increase the Risk of Endometriosis? A Combined Population‑Based and Laboratory Study.

Endometriosis is a chronic, estrogen-dependent inflammatory disorder that causes substantial pain and infertility. Observational studies have reported higher rates of multiple psychiatric disorders among individuals with endometriosis; however, confounding and …

Published: May 22, 2026, midnight
From gut-reproductive microbiota to ferroptosis: a comprehensive insight into the molecular-pathogenicity of endometriosis.

Endometriosis (EMS) is a highly heterogeneous chronic gynecological disease characterized by pain, infertility, and relapse, with its etiology and pathogenesis not yet fully elucidated. Traditional theories, including "retrograde menstruation," "implantation …

Published: May 22, 2026, midnight
Lead concentration in follicular fluid of infertile patients with and without endometriosis: a propensity score matching exploratory study.

This preliminary study sought to provide initial insights into lead concentrations within the follicular fluid of infertile patients with and without endometriosis, tentatively observing any potential links between lead presence …

Published: May 22, 2026, midnight
Follicular fluid-derived exosomal LINC02701 promotes granulosa cell apoptosis through the GRP75-P53 axis in active endometriosis.

Endometriosis (EMs)-associated infertility has been linked to alterations in the follicular microenvironment; however, the role of exosomal long non-coding RNAs (lncRNAs) in granulosa cell dysfunction remains incompletely understood.

Published: May 22, 2026, midnight
Correlations Between Ultrasound Features and Histological Findings in Adenomyosis: A Single-Center Retrospective Study.

Adenomyosis is a benign gynecologic condition characterized by ectopic endometrial glands and stroma present within the myometrium. Background/Objectives: The gold standard in diagnosis is the histology of hysterectomy specimens. Due …

Published: May 22, 2026, midnight
Does endometrioma diameter impact serum anti-Müllerian hormone levels? A systematic review and meta-analysis.

Is endometrioma diameter associated with ovarian reserve, as reflected by serum anti-Müllerian hormone (AMH) levels, in women of reproductive age with no history of ovarian surgery?

Published: May 22, 2026, midnight
ENDOMETRIOSIS AND ENDOMETRIAL POLYPS CO-OCCURRENCE IN INDIVIDUALS NOT SEEKING PREGNANCY: A CASE-CONTROL STUDY.

Endometriosis and endometrial polyps are both estrogen-dependent conditions, and an association between these two pathologies has been observed in infertile women. Our research question was: "Is there an association between …

Published: May 21, 2026, midnight
Developmental Versus Chromosomal Competence in Endometriosis: A Stepwise IVF Outcome Analysis.

Background and Objectives: Endometriosis is a multifactorial gynecological condition associated with impaired fertility; however, its impact on embryo competence remains incompletely understood. This study aimed to evaluate embryo competence through …

Published: May 21, 2026, midnight
Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis.

Deep infiltrating endometriosis (DIE) is a highly fibrotic and deeply invasive subtype of endometriosis that causes severe pelvic pain, infertility and marked impairment of quality of life. Metabolic, microbial and …

Published: May 21, 2026, midnight
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