[This corrects the article DOI: 10.1371/journal.pone.0057724.].
Pain is the primary symptom of endometriosis and may progress into a chronic, acyclic condition driven by neuroinflammatory mechanisms, leading to neuropathic and ultimately nociplastic pain. Central sensitization, a form …
Endometriosis is a heterogeneous pain condition with variable symptom expression. Abuse history has been associated with amplified pain, gastrointestinal symptoms, and central sensitization in varying populations; however, whether these effects …
Endometriosis (EMS) is characterized by pain symptoms that seriously affect patients' quality of life. Gut microbiome-related metabolites (GMRM) play an important role in the process of EMS. However, the role …
The human microbiota is increasingly recognized as a key component of women's reproductive health. This narrative review examines the vaginal, endometrial, and gut microbiota and their roles in the pathogenesis …
Does PIEZO1 play any role in adenomyosis-associated dysmenorrhea?
Endometriosis is a chronic inflammatory gynecological disease affecting approximately 10% of women of reproductive age and is associated with pelvic pain, infertility, and reduced quality of life. Increasing evidence suggests …
Background/Objectives: Endometriosis is a prevalent gynecological illness associated with chronic pain, inflammation, and infertility, as ectopic endometrial lesions are formed. No fully effective treatment is available, and the pathogenesis of …
Professional societies recommend opportunistic salpingectomy during vaginal hysterectomy to reduce the risk of ovarian cancer, but it may be technically challenging without uterine prolapse. We examined national patterns, patient and …
To evaluate the efficacy and tolerability of the gonadotropin-releasing hormone antagonist elagolix for endometriosis-associated pain symptoms in adolescents and young adults (AYA).