Endometriosis and Endometrial Cancer-Association Between Biological Mechanisms and Its Clinical Implications.
Endometriosis and endometrial cancer are distinct gynecological conditions that share overlapping biological mechanisms with implications for clinical management. Endometriosis is a chronic, benign disorder characterized by the ectopic implantation of …
The AGCES Classification System for Endometriosis: Integrating Adenomyosis with Genital and Extragenital Staging-An Expert Consensus Framework from the American & Global College of Endometriosis Specialists (AGCES).
Background: Current endometriosis classification systems have important limitations in accurately describing total disease burden and predicting clinical outcomes. Existing staging frameworks often fail to integrate adenomyosis and do not adequately …
Non-Mineral Antioxidant Supplementation in Endometriosis: Biological Rationale, Clinical Evidence, and Therapeutic Implications-A Narrative Review.
Background/Objectives: Oxidative stress plays an important role in the pathophysiology of endometriosis, contributing to inflammation, immune dysregulation, and lesion progression. This has led to growing interest in antioxidant-based strategies as …
Is colorectal resection necessary to improve pain and fertility outcomes in patients with deep endometriosis?
Bowel endometriosis is often considered an indication for extensive surgical management, including colorectal resection, in women undergoing surgery for concomitant endometriosis at other sites. However, several contemporary studies show little …
Role of soluble EGFR, Fas, and Fas ligand in pelvic pain severity and their association with endometriosis in infertile woman: a case-control study.
Endometriosis, a chronic inflammatory condition linked to pelvic pain and infertility, is characterized by immune dysfunction involving dysregulated apoptosis and cell proliferation. This case-control study included 87 infertile women undergoing …
Prediction of endometrial tissue PFAS concentrations using serum levels, demographic, and reproductive factors: Findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) study.
Per- and polyfluoroalkyl substances (PFAS) accumulate in reproductive tissues, yet most studies rely on serum measurements. It remains unclear whether serum concentrations adequately reflect levels in target tissues. We evaluated …