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Bidirectional Mendelian randomization and cross-sectional study reveal depression as a causal risk factor for endometriosis.

Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study …

Published: Nov. 21, 2025, midnight
Bioinformatic analysis and validation of candidate genes in the eutopic endometrium reveal differential expressions in diffuse adenomyosis, endometrioma, and their co-existence.

Adenomyosis and endometriosis are hormone-dependent benign gynecological disorders with overlapping features suggesting that they may share a common origin despite being considered distinct entities. This study compares the expression of …

Published: Nov. 21, 2025, midnight
MiRNome alterations drive the malignant transformation of endometriosis into endometriosis-correlated ovarian cancer.

Endometriosis (EMS) is a chronic gynecological condition affecting 6-10% of reproductive-age women. These lesions, albeit of benign nature, present cancer-like features, and may progress to epithelial ovarian cancer (EOC) through …

Published: Nov. 21, 2025, midnight
THBS1 identificated as an endometriosis biomarker through evidence from single-cell and bulk transcriptomic profiling.

Endometriosis affects a substantial number of women of reproductive age, yet current diagnostic methods rely on invasive procedures. To address this limitation, we investigated THBS1 as a potential biomarker and …

Published: Nov. 21, 2025, midnight
Endometriosis - on the intersection of modern environmental pollutants and ancient genetic regulatory variants - Nature

Endometriosis - on the intersection of modern environmental pollutants and ancient genetic regulatory variants Nature

Published: Nov. 20, 2025, 5:11 p.m.
Establishment and Characterization of a New Immortalized Human Adenomyosis Epithelial-Like Cell Line, tAEC21†.

Adenomyosis occurs when endometrial glands and stroma grow within the uterine myometrium. As a clinically significant disease, adenomyosis causes substantial pelvic pain and heavy menstrual bleeding. It remains understudied due …

Published: Nov. 20, 2025, midnight
Endometriosis - on the intersection of modern environmental pollutants and ancient genetic regulatory variants.

Endometriosis is a chronic, estrogen-driven inflammatory disorder affecting approximately 10% of reproductive-aged women globally. Despite increasing genomic insights into advanced-stage disease, the genetic underpinnings of early-stage endometriosis remain poorly understood, …

Published: Nov. 20, 2025, midnight
Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis.

Endometriosis-associated ovarian carcinoma (EAOC) predominantly arises from the malignant transformation of endometriomas, yet the mechanism is incompletely defined. Spatial transcriptomic analysis of human specimens of normal endometrium, endometriomas, and EAOC …

Published: Nov. 20, 2025, midnight
Extracellular Trap-Related Genes as Potential Diagnostic Biomarkers for Endometriosis.

Endometriosis (EM), a prevalent gynecological disorder in reproductive-age women, lacks reliable noninvasive diagnostic tools. EM may be detected by neutrophil extracellular traps (NETs), which are essential to inflammation and immunological …

Published: Nov. 19, 2025, midnight
Per- and polyfluoroalkyl substances exposure and endometriosis risk: Evidence from epidemiologic, network toxicology, and molecular docking.

Although per- and polyfluoroalkyl substances (PFAS) exposure has been linked to endometriosis, this association remains controversial, and the underlying mechanisms are unclear. This study aimed to investigate this relationship and …

Published: Nov. 19, 2025, midnight
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