The letrozole use in reproductive medicine: Beyond aromatase inhibition - a comprehensive review.
Letrozole and other aromatase inhibitors are increasingly recognized as first-line ovulation induction (OI) medications, offering an efficient and physiologic approach to ovarian stimulation that enhances outcomes in reproductive medicine. By …
Mechanism of Bushen Wenyang Huayu Formula against oxidative damage by Let-7b-Bach1 in the treatment of endometriosis.
Endometriosis (EMs) is a prevalent and challenging gynecological disease and current therapeutic outcomes are suboptimal. Traditional Chinese medicine (TCM) has numerous advantages in treating EMs. Bushen Wenyang Huayu Formula (BWHF), …
Association Between Body Fat Percentage and Endometriosis Severity Based on American Association of Gynecologic Laparoscopists 2021 Endometriosis Classification.
Endometriosis is one of the main reproductive issues that the modifiable risk factors is still the main research focus. It is still unclear how various adiposity affect the onset and …
Soluble Mediators Related to Immunity in Pregnancy-Related Disorders: Roles of Immune Checkpoints, Platelet Activation Markers, TNF Receptors, and NETs.
Soluble immune mediators are key regulators of immune responses that help maintain self-tolerance and prevent autoimmunity. Recently, many forms of these mediators have been found, including soluble immune checkpoints, soluble …
A Previous History of Endometriosis Elevates Irritable Bowel Syndrome Risk in Middle-Aged and Older Women: A UK Biobank Cohort Study of 225,703 Participants.
Endometriosis (EMT) and irritable bowel syndrome (IBS) disproportionately affect middle-aged and older women, where overlapping symptoms (e.g., chronic pelvic pain, bloating) and shared inflammatory mechanisms may drive comorbidity. However, large-scale …
Precision-based solutions for endometriosis: Integrating immunomics and drug repositioning strategies.
Endometriosis (EMs) is an estrogen-dependent, chronic inflammatory disorder characterized by immune microenvironment dysregulation, a critical factor in its pathogenesis. Despite existing therapies, limitations persist, highlighting the urgent need for innovative …