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Research progress on m6A RNA methylation modification in human reproduction related diseases.

A healthy reproductive system is fundamental to human fertility. N6-adenosine methylation (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role in regulating RNA metabolism, including splicing, degradation, …

Published: Dec. 1, 2025, midnight
Risk of cardiovascular disease and mortality among women with endometriosis: A systematic review and meta-analysis.

Endometriosis is a chronic and estrogen-dependent disorder that affects about 10% of women of reproductive age worldwide. Endometriosis has been associated with chronic inflammation and an atherogenic lipid profile, two …

Published: Nov. 27, 2025, midnight
m6A-Related SNPs in endometriosis and ovarian cancer: implications for chemoresistance and therapeutic targeting.

Ovarian cancer (OC) is highly lethal, largely due to late diagnosis and chemoresistance. Endometriosis (EM) increases the risk of specific OC subtypes, but the molecular connection between the two diseases …

Published: Nov. 27, 2025, midnight
Bidirectional Mendelian randomization and cross-sectional study reveal depression as a causal risk factor for endometriosis.

Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study …

Published: Nov. 21, 2025, midnight
Adenomyosis in patients with rheumatic diseases: a cross-disciplinary clinical observation.

Autoimmune and inflammatory rheumatic diseases (RDs) are more prevalent in women and often affect gynecological health. Particularly, heavy menstrual bleeding (HMB) and dysmenorrhea are more common in patients with RD. …

Published: Nov. 18, 2025, midnight
The role of mitophagy in female reproductive system diseases: from molecular mechanisms to therapeutic strategies.

Mitophagy is a catabolic mechanism that selectively degrades damaged mitochondria and precisely modulates mitochondrial content, thereby maintaining intracellular homeostasis under stress conditions. To date, most reviews on mitophagy have predominantly …

Published: Nov. 18, 2025, midnight
Circulating miRNA as diagnostic tools for gynecological diseases and their applications in biosensor development.

MicroRNAs (miRNAs) have emerged as robust biomarkers for diagnosing and prognosing gynecological diseases due to their disease-specific expression and remarkable stability in body fluids. Despite the inherent instability of RNA …

Published: Nov. 15, 2025, midnight
Association Between the C-Reactive Protein-Albumin-Lymphocyte Index and Endometriosis: Insights from the 1999-2006 National Health and Nutrition Examination Survey.

The C-reactive protein-albumin-lymphocyte (CALLY) index serves as an integrated indicator, reflecting the interplay between systemic inflammation, immune competence, and nutritional health. While validated in other chronic diseases, its relevance to …

Published: Nov. 7, 2025, midnight
Spontaneous Pneumothorax: A Review of Underlying Etiologies and Diagnostic Imaging Modalities.

This review focuses on the diverse etiologies of secondary spontaneous pneumothorax (SSP) and the crucial role of imaging in their diagnosis. Unlike primary spontaneous pneumothorax (PSP), which is typically due …

Published: Nov. 7, 2025, midnight
Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential.

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival …

Published: Nov. 5, 2025, midnight
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