Endometriosis is a complex disease that may affect a woman's fertility and quality of life. Owing to substantial variations in symptom severity, lesion distribution, and reproductive impact, its management presents …
Inflammatory resolution is essential for tissue health, yet its dynamics remain difficult to study in humans. Menstruation is a recurrent, non-pathological inflammatory process that provides a natural window into inflammation …
Abnormal uterine bleeding (AUB), particularly when associated with uterine leiomyomas, is a frequent cause of iron deficiency anemia among women of reproductive age. While commonly manageable, in rare instances, AUB …
The extracellular matrix (ECM) critically influences cell behavior, yet its properties in human endometrial lesions (HEL) and human uterine fibromas (HUF) are not well characterized. This study aimed to characterize …
The human microbiome, particularly the gut and reproductive tract microbiota, plays a critical role in regulating fertility through complex molecular and immunological mechanisms. This review synthesizes emerging evidence on the …
From an immunological perspective, infertility mechanisms encompass not only fertilization but also implantation, as well as both early and late pregnancy loss. Growing attention is being directed towards the influence …
Adult endometrial glands undergo cyclic regeneration and development during the menstrual cycle. Their secretions are vital for endometrial functions and early pregnancy, yet the mechanisms controlling gland development are not …
Peritoneal endometriosis causes pelvic pain and infertility, but the underlying mechanisms related to these symptoms are not fully understood. Endometriosis diagnosis is typically delayed; thus, patient samples are unsuitable to …
Human papillomavirus (HPV) is a well-established etiological agent for cervical cancer, yet its contribution to endometrial malignancies remains underrecognized and mechanistically distinct. This paper synthesizes current evidence to explain the …
Endometriosis (EM) is a persistent, chronic inflammatory condition associated with excruciating pelvic pain and infertility. The absence of a pre-clinical model that reliably replicates the clinical and functional hallmarks of …