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New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials.

Endometriosis is a common chronic gynecological condition that affects approximately 10% of women of reproductive age worldwide.

Published: Aug. 15, 2025, midnight
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases.

The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including …

Published: Aug. 14, 2025, midnight
Risk of Self-Harm Among Individuals Diagnosed With Endometriosis.

Endometriosis is a chronic inflammatory condition that has been linked to mental health outcomes. We conducted a population-based, retrospective, matched cohort study using administrative health data (2010-2022) from Ontario, Canada, …

Published: Aug. 14, 2025, midnight
Different ultrasound morphologies of rectosigmoid endometriosis nodules: an exploratory analysis of their prevalence and associated clinical characteristics.

To investigate the prevalence of various ultrasound morphologies of rectosigmoid endometriosis (RSE) nodules according to the International Deep Endometriosis Analysis (IDEA) consensus, and their potential association with distinct clinical phenotypes …

Published: Aug. 14, 2025, midnight
Single-Cell Profiling Reveals Altered Endometrial Cellular Features Across the Menstrual Cycle in Endometriosis Patients.

Endometriosis is a chronic, estrogen-dependent condition affecting over 190 million women globally, characterized by the ectopic presence of endometrial-like tissue that leads to inflammation, pain, and infertility. Despite its prevalence, …

Published: Aug. 14, 2025, midnight
Impact of a National Public Health Plan on the time frame for moderate and severe endometriosis diagnosis.

to study the time from symptom onset to the diagnosis of moderate and severe endometriosis and to compare this delay before and after the implementation of a National Endometriosis Public …

Published: Aug. 14, 2025, midnight
Global, regional, and national burdens of endometriosis from 1990 to 2021: a trend analysis.

Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehensive data …

Published: Aug. 14, 2025, midnight
Polypoidal rectal endometriosis-a diagnostic dilemma.

Polypoidal rectal endometriosis is a rare and diagnostically challenging manifestation of deep infiltrating endometriosis that may mimic colorectal malignancy, especially in women lacking classical cyclical symptoms. We report such a …

Published: Aug. 13, 2025, midnight
AntiCD44 antibody-conjugated gold nanoparticles for targeted photothermal therapy of endometriotic cells.

Endometriosis is a chronic gynecologic disease that needs newer and safer treatments. The proposed work aims to develop a nanosystem based on gold nanoparticles (AuNPs) to actively target human endometriosis …

Published: Aug. 13, 2025, midnight
Mathematical modelling of macrophage and natural killer cell immune response during early stages of peritoneal endometriosis lesion onset.

The immune system is hypothesized to contribute to the onset of endometriosis lesions. However, the precise mechanisms underlying its role are not yet known. We introduce a novel compartmental model …

Published: Aug. 13, 2025, midnight
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