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Oxidative Stress-Telomere Axis in IVF: Molecular Mechanisms, Biomarkers, and Clinical Translation.

The reduction in oocyte competence and ovarian reserve coincides with reproductive ageing; nevertheless, the molecular mechanisms underlying this phenomenon remain poorly understood. Our testable mechanistic hypothesis is that the oxidative …

Published: Nov. 24, 2025, midnight
Progesterone and IL-6 Expression Are Modulated by Follicular Fluid in Granulosa Cell Cultures.

Endometriosis (ENDO) and poor ovarian response (POR) represent challenging conditions in assisted reproduction. Both, associated with altered follicular fluid (FF) composition, specifically impact on granulosa cell (GC) function in an …

Published: Nov. 23, 2025, midnight
Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas.

Endometriosis involves ectopic growth of endometrial-like tissue, yet the spatial transcriptomic and metabolic landscape of ovarian endometriomas remains poorly understood. This investigation presents a comprehensive multi-omics analysis of ovarian endometriomas …

Published: Nov. 22, 2025, midnight
The Hugo™ RAS system in gynecologic robotic surgery: a systematic review of current applications.

The Hugo™ Robotic-Assisted Surgery (RAS) system is a recent development in minimally invasive gynecologic surgery. Following regulatory approval, its clinical use has expanded. However, comprehensive evidence on feasibility, safety and …

Published: Nov. 17, 2025, midnight
''Non-Invasive Extracellular Vesicle Biomarkers in Endometriosis, Molecular Signatures Linking Pelvic Inflammation, Oocyte Quality, and IVF Outcomes''.

Endometriosis impairs fertility by interfering with ovarian function, embryonic development, and endometrial receptivity. Extracellular vesicles (EVs) are recognised as non-invasive biomarkers that may indicate biological processes based on their lipid, …

Published: Nov. 17, 2025, midnight
The Evolution of In Vitro Fertilization Practices in Saudi Arabia: Historical Perspectives and Future Directions.

In vitro fertilization (IVF) has revolutionized assisted reproductive technologies (ART), profoundly transforming infertility treatment since its inception. This procedure involves fertilizing an egg with sperm in a controlled laboratory environment, …

Published: Nov. 16, 2025, midnight
Robot-assisted resection of diaphragmatic and hepatorenal recess peritoneal endometriosis: Two cases and a narrative review.

In this report, we describe two cases of diaphragmatic endometriosis with concurrent hepatorenal recess peritoneal involvement managed using robotic-assisted laparoscopic surgery with the da Vinci Xi platform. In both patients, …

Published: Nov. 15, 2025, midnight
Natural procreative technology (NaProTechnology) for infertility: take-home baby rate and clinical outcomes in a 5-year single-center cohort of 1,310 couples.

Assisted reproductive technologies (ART) are widely used to address infertility; however, they are costly, associated with medical risks, and often yield suboptimal clinical outcomes. Natural Procreative Technology, also known as …

Published: Nov. 14, 2025, midnight
In vitro fertilization-assisted pregnancy combined with high-intensity focused ultrasound treatment in patients with endometriosis and adenomyosis with successful pregnancy: a case report.

High-intensity focused ultrasound ablation has emerged as a noninvasive therapeutic option for adenomyosis of the uterus. We studied a female with infertility patient to explore the application of in vitro …

Published: Nov. 5, 2025, midnight
Opioid Use After Robotic Assisted versus Laparoscopic Endometriosis Surgery.

Minimally invasive endometriosis surgery can be done laparoscopically or with robotic assistance. The choice of modality of this procedure could impact postprocedure pain levels and the need for opioids to …

Published: Nov. 3, 2025, midnight
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