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CXCL12 promotes EMT-mediated malignant transformation of endometriosis-associated ovarian cancer via PI3K/Akt signaling: An integrated transcriptomic and clinical study.

Endometriosis-associated ovarian cancer (EAOC) is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition (EMT) is acknowledged as a …

Published: Jan. 16, 2026, midnight
Unraveling the VEGF-ETS1 axis: a transcriptomic and single-cell analysis of angiogenesis in endometriosis.

Endometriosis (EM) is a chronic inflammatory gynecological disorder characterized by ectopic endometrial-like lesions, where aberrant angiogenesis is a hallmark driving lesion establishment and progression. However, the transcriptional mechanisms underlying pathological …

Published: Jan. 16, 2026, midnight
Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.

Endometriosis is traditionally conceptualized as a pelvic lesion-centered disease; however, mounting evidence indicates it is a chronic, systemic, and multifactorial inflammatory disorder. This review examines the molecular dialog between ectopic …

Published: Jan. 16, 2026, midnight
Investigation of endothelin-1 receptor antagonist bosentan in a rat endometriosis model.

The study aimed to investigate the roles of endothelin-1 and endothelin receptors in a rat endometriosis model and to demonstrate how bosentan (BOS), an endothelin receptor blocker, could potentially serve …

Published: Jan. 14, 2026, midnight
Intense 68Ga-FAPI-04 Uptake in a Rare Case of Multifocal Abdominal Wall Endometriosis.

Fibroblast activation protein inhibitor (FAPI) PET is an emerging molecular imaging modality that is widely used in oncology and increasingly investigated in nononcologic diseases. Abdominal wall endometriosis (AWE) is a …

Published: Jan. 13, 2026, midnight
Uncommon diagnostic aspects of adolescent endometriosis: case series with narrative review of the literature.

Endometriosis is a gynecological disorder for which awareness and detection rates are rising globally. The purpose of this study is to highlight atypical presentations of the disease; to present four …

Published: Jan. 12, 2026, midnight
Aquaporin-9 and Endometriomas: Pathophysiological Insights from a Case-Control Study.

Endometriosis is an estrogen-dependent condition characterized by ectopic implantation of endometrial tissue, yet the molecular mechanisms underlying lesion persistence remain incompletely understood. Aquaporins (AQPs), transmembrane water channels involved in cellular …

Published: Jan. 10, 2026, midnight
Surgical Management of Disseminated Peritoneal Leiomyomatosis.

The objective of this video is to describe a case of disseminated peritoneal leiomyomatosis (DPL) mimicking deeply infiltrating endometriosis and discuss the preoperative workup, intraoperative approach, and postoperative considerations. We …

Published: Jan. 9, 2026, midnight
Regarding "Is endometriosis staging related to the type and intensity of patients' complaints? A systematic review and meta-analysis".

Firstly, this meta-analysis[1] included a total of eight studies, seven of which used the rASRM classification, while only one applied the ENZIAN classification; the latter was not included in the …

Published: Jan. 9, 2026, midnight
Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review.

Numerous abnormalities of the endometriosis eutopic endometrium contribute to the initiation and development of ectopic lesions. It is also believed that among the complex causes of the disease, systemic immunological …

Published: Jan. 8, 2026, midnight
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