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Primary Invasive Squamous Cell Carcinoma of the Vagina Presenting Three Decades After Total Hysterectomy for Benign Endometriosis: A Case Report.

A 57-year-old woman (G2P2) with a history of total hysterectomy for endometriosis 30 years earlier, presented for a routine gynecological examination without complaints. Speculum examination revealed an erythematous, raised plaque …

Published: Oct. 23, 2025, midnight
Addressing Meta-Inflammation in the Comprehensive Management of Chronic Pain.

Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …

Published: Oct. 18, 2025, midnight
Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study.

Background/Objectives: Endometriosis is a chronic inflammatory systemic disease that commonly affects bowel structures, including the appendix, where it may mimic or coexist with chronic appendicitis. Visual inspection alone often fails …

Published: Oct. 15, 2025, midnight
Mechanism of vascular endothelial growth factor regulating hypoxia and inflammatory microenvironment in endometriosis: based on bioinformatics and multi-level validation.

Endometriosis remains a prevalent gynecological disorder that affects women during their reproductive years, featured by progressive inflammation and enhanced HIF-1α expression. This paper intended to plumb the mechanism of vascular …

Published: Oct. 10, 2025, midnight
Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System.

The ascent of novel alternative methods (NAMs) in drug development spotlights the dual needs for improved biological fidelity to in vivo along with reproducibility, especially in regulatory applications. The need …

Published: Oct. 6, 2025, midnight
Molecular Pathogenesis of Ovarian Endometrioma: Mechanistic Insights and Therapeutic Implications.

Ovarian endometrioma (OMA), the most prevalent and clinically consequential subtype of endometriosis, represents a chronic inflammatory disorder characterized by ectopic endometrial-like lesions. This condition manifests as progressive dysmenorrhea, ovarian reserve …

Published: Oct. 4, 2025, midnight
Reproductive History and Cardio-Metabolic Risk in the Postmenopausal Age.

Menopause represents a cardio-metabolic transition, but cardiovascular (CV) health in women is highly influenced by other reproductive milestones and conditions, which delineate a cardio-reproductive lifeline. Reproductive history represents an opportunity …

Published: Sept. 30, 2025, midnight
Long-term health consequences of childhood adverse events: A narrative review.

"Adverse childhood events" or childhood adversity is a term often used to describe trauma and sources of stress during childhood or adolescence. Childhood adversity may negatively affect multiple aspects of …

Published: Sept. 26, 2025, midnight
Ultrasound Findings in Endosalpingiosis: A Closer Look at an Overlooked Condition.

Endosalpingiosis is a rare, benign condition characterized by ectopic cystic glands lined with ciliated cuboidal epithelium, histologically resembling the fallopian tube. Its etiology remains uncertain but is hypothesized to result …

Published: Sept. 23, 2025, midnight
Clinical Application of Cell Therapy in the Treatment of Female Reproductive Diseases: A Systematic Review.

Reproductive disorders affect millions of women worldwide, playing a crucial role in determining female fertility health and quality of life. Conventional methods such as surgery, hormone therapy, and assisted reproductive …

Published: Sept. 23, 2025, midnight
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