Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.
Endometriosis, defined as the ectopic growth of endometrial tissue outside of the uterine cavity, is an inflammatory and hormone-dependent disease that causes excruciating pelvic pain, infertility, and significantly decreases quality …
Clinical Appraisal of "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy".
This paper critically evaluates Sekiguchi et al.'s study of vaginal progesterone dose, serum progesterone thresholds, and reproductive outcomes in hormone replacement therapy frozen embryo transfer (HRT-FET) cycles. The study conflates …
Time to Diagnose for Adolescent Endometriosis in West Java, Indonesia Population: A Single Centre 2 Years Retrospective Descriptive Study.
Endometriosis affects approximately 10% of reproductive-age women and up to 20% of those with infertility. Despite rising awareness in adults, adolescent endometriosis remains underrecognized, especially in Southeast Asia. This study …
Endometriosis-associated bone loss: re-evaluating the potential role of systemic inflammation and hypoestrogenic therapies.
Endometriosis is frequently managed with hormonal suppression that can induce hypoestrogenism during a period when many patients are still accruing peak bone mass. This narrative review summarizes current clinical and …
Exploring the exercise dose to induce symptomatic and biomarker change in endometriosis: A protocol for a randomised controlled trial.
Exercise may be an effective tool to improve symptoms and quality of life in those with endometriosis. However, the optimal dose to elicit such changes is unknown. This study will …