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newsGP - Parkinson’s and melanoma added to PBS - Royal Australian College of General Practitioners (RACGP)

newsGP - Parkinson’s and melanoma added to PBS Royal Australian College of General Practitioners (RACGP)

Published: Sept. 12, 2025, 6:14 a.m.
Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.

Endometriosis is characterized by the presence of endometrial tissue outside the uterine cavity. The administration of drugs designated for this condition has significant adverse effects, such as signs of estrogen …

Published: Sept. 12, 2025, midnight
M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits.

Endometriosis is a common gynecologic condition that causes chronic, life-altering symptoms including pain and infertility. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but until …

Published: Sept. 12, 2025, midnight
Helixor A enhances natural killer cell activity by induction of PAI-1 expression through the p38/MAPK signaling pathway.

Helixor A, an anticancer drug, has an immunostimulatory effect that increases T and natural killer (NK) cell activity in patients with cancer and endometriosis. However, the molecular mechanisms underlying its …

Published: Sept. 12, 2025, midnight
Understanding Endometriosis: A Broad Review of Its Causes, Management, and Impact.

Endometriosis is a complex gynecological condition affecting 10% of women globally, characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, infertility, reduced quality of …

Published: Sept. 12, 2025, midnight
Efficacy of Elagolix and Relugolix for the Treatment of Pelvic Pain in Patients With Endometriosis: A Systematic Review.

Endometriosis is a chronic gynecological condition commonly associated with pelvic pain, dysmenorrhea, dyspareunia, and infertility. Owing to the limitations and adverse effects of traditional hormonal therapies, this study aimed to …

Published: Sept. 12, 2025, midnight
Determination of Apoptotic Pathways in Ovarian Folicular Fluid of Infertile Patients With Endometrioma in Relation to Follicular Atresia.

Endometriosis is a chronic inflammatory disease that leads to pelvic pain and infertility. Recent studies have indicated that immunological, endocrine, biochemical, and genetic irregularities, along with suboptimal quality of oocytes, …

Published: Sept. 10, 2025, midnight
The Role of Endometriosis in Intestinal Inflammation: A Combined Mendelian Randomization and Cellular Study.

This study aims to assess whether endometriosis causally increases the risk of IBD through Mendelian randomisation (MR) analysis and to elucidate potential mechanisms using in vitro experiments. A two-sample Mendelian …

Published: Sept. 10, 2025, midnight
Identification and Exploration of Novel B Cell Infiltration-Related Biomarkers in Endometriosis.

To explore B cell infiltration-related genes in endometriosis (EM) and investigate their potential as diagnostic biomarkers.

Published: Sept. 10, 2025, midnight
Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis.

This study evaluated the feasibility of single-nucleotide polymorphism (SNP) genotyping using dried blood spot (DBS) samples stored under various conditions, based on the genotyping success rate and concordance with whole …

Published: Sept. 10, 2025, midnight
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