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Pharmacokinetic-Pharmacodynamic Modeling and Simulation of Merigolix, a Nonpeptide Gonadotropin-Releasing Hormone Antagonist.

Gonadotropin-releasing hormone (GnRH) antagonists inhibit estrogen synthesis and secretion, making them promising treatment options for estrogen-dependent diseases, such as endometriosis. This study developed a population pharmacokinetic/pharmacodynamic (PK/PD) model for merigolix, …

Published: Dec. 20, 2025, midnight
Non-Invasive Diagnosis of Endometriosis by Questionnaires in Patients Using Contraception.

Background/Objectives: The assessment of endometriosis (EMS)-associated pain is important, but only very few studies address the potential use of questionnaires for non-invasive prediction of the disease. Methods: In a prospective …

Published: Dec. 20, 2025, midnight
Pedestrian died after being hit by 2 vehicles on dark road - Essex Live

Pedestrian died after being hit by 2 vehicles on dark road Essex Live

Published: Dec. 19, 2025, 11:31 a.m.
Correlation between Polycomb repressive complex proteins and epithelial-mesenchymal transition-associated genes in endometriotic tissues.

Endometriosis is a condition in which functional endometrial glands and stroma are found to grow outside the uterine cavity that can lead to symptoms like dysmenorrhea, dyspareunia, adhesions, and infertility. …

Published: Dec. 19, 2025, midnight
Endometriosis Involving the Bladder: A Contemporary Clinicopathologic Analysis of 88 Patients.

Predominantly, case reports and small case series of endometriosis involving the bladder have been published. This study aimed to provide a contemporary clinicopathologic analysis of a large cohort of patients …

Published: Dec. 17, 2025, midnight
Borderline ovarian clear cell tumor arising from endometriosis during long-term dienogest therapy: a case report.

Endometriomas, commonly known as ovarian chocolate cysts, are a prevalent condition in women of reproductive age. They are cysts formed by the ectopic growth of endometrial tissue within the ovary, …

Published: Dec. 17, 2025, midnight
Rachael Carpani, McLeod’s Daughters and Home and Away actor, dies ‘unexpectedly but peacefully’ aged 45 - The Guardian

Rachael Carpani, McLeod’s Daughters and Home and Away actor, dies ‘unexpectedly but peacefully’ aged 45 The Guardian

Published: Dec. 16, 2025, 7:19 p.m.
McLeod’s Daughters star Rachael Carpani dies age 45: Her brave 20-year battle to help other women - 7NEWS

McLeod’s Daughters star Rachael Carpani dies age 45: Her brave 20-year battle to help other women 7NEWS

Published: Dec. 16, 2025, 3:14 a.m.
Beloved McLeod's Daughters actress Rachael Carpani has died unexpectedly, age 45. - Mamamia

Beloved McLeod's Daughters actress Rachael Carpani has died unexpectedly, age 45. Mamamia

Published: Dec. 16, 2025, 1:21 a.m.
Rachael Carpani, "NCIS: Los Angeles" actress, dies at 45 - MSN

Rachael Carpani, "NCIS: Los Angeles" actress, dies at 45 MSN

Published: Dec. 16, 2025, 12:23 a.m.
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