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The vicious cycle of chronic endometriosis and depression-an immunological and physiological perspective.

Endometriosis is a chronic, estrogen-dependent, proinflammatory disease that can cause various dysfunctions. The main clinical manifestations of endometriosis include chronic pelvic pain and impaired fertility. The disease is characterized by …

Published: Sept. 6, 2024, midnight
The rs2046210 Polymorphism Is Associated with Endometriosis Risk and Elevated Estrogen Receptor 1 Expression in the Eutopic Endometrium of Women with the Disease.

In this focused genetic case-control study, we analyzed two functional single-nucleotide variants (SNVs) associated with breast cancer risk (rs2046210, rs9383590) and one risk SNV for an implantation defect and infertility …

Published: July 25, 2024, midnight
Comparative Analysis of Shapley Values Enhances Transcriptomics Insights across Some Common Uterine Pathologies.

Uterine pathologies pose a challenge to women's health on a global scale. Despite extensive research, the causes and origin of some of these common disorders are not well defined yet. …

Published: June 1, 2024, midnight
Altered gene expression of VEGF, IGFs and H19 lncRNA and epigenetic profile of H19-DMR region in endometrial tissues of women with endometriosis.

Endometriosis, as chronic estrogen-dependent disease, is defined by the presence of endometrial-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are critical factors in development of endometriosis. Hence, …

Published: April 22, 2022, midnight
Bioinformatical analysis of the key differentially expressed genes and associations with immune cell infiltration in development of endometriosis.

This study explored the key genes related to immune cell infiltration in endometriosis.

Published: March 18, 2022, midnight
An Insight on the Role of Altered Function and Expression of Exosomes and MicroRNAs in Female Reproductive Diseases.

Exosomes are small bilayer-lipid membrane vesicles secreted by living cells that are able to transfer regulatory molecules and genetic information from one cell to another. These vesicles are enriched with …

Published: April 6, 2021, midnight
Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats.

Endometriosis, as the leading cause of infertility, is attributed to oxidative stress, inflammation, and autophagy dysregulation. This study was conducted to evaluate the effect of quercetin and metformin, alone or …

Published: Nov. 3, 2020, midnight
Interaction of sperm with endometrium can regulate genes involved in endometrial receptivity pathway in mice: An experimental study.

Many researchers consider implantation and endometrial receptivity as pertinent issues in reproductive science. Although, several experiments have been performed and their results evaluated, yet there is no confirmed evidence about …

Published: Oct. 13, 2020, midnight
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