Endometriosis is a medical condition where endometrial tissue and glands are found outside the uterine cavity: on ovaries, pelvic peritoneum, rectovaginal septum, bladder, bowel and more. The ectopic tissue is …
Immune-related factors may serve an important role in the development of endometriosis, considering the occurrence of substantial abnormalities in the immune system of women with endometriosis, including reduced T-cell reactivity …
Menstrual blood (MB), a biofluid rich in diverse cell types and biomolecules, has emerged as a vital resource for investigating female reproductive health and diseases because of its unique composition …
Endometriosis is a chronic inflammatory disease affecting women of reproductive age, often accompanied by chronic pelvic pain and infertility. Despite numerous studies, its pathogenesis remains incompletely understood. Increasing evidence indicates …
Endometriosis poses significant challenges for women of reproductive age, particularly due to its impact on ovarian reserve and fertility. In addition to endometriosis-associated infertility contributing to diminished ovarian reserve by …
Endometriosis, chronic endometritis (CE), unexplained infertility (UI), and recurrent pregnancy loss (RPL) are gynecological conditions frequently associated with inflammation and alterations in the endometrial microbiome. The presence of bacterial vaginosis-associated …
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including …
Endometriosis is a chronic, estrogen-dependent condition affecting over 190 million women globally, characterized by the ectopic presence of endometrial-like tissue that leads to inflammation, pain, and infertility. Despite its prevalence, …
Integrated transcriptomic and proteomic analysis reveals that the anti-endometriosis effects of Pingchong Jiangni recipe may involve pathways and genes/proteins related to inflammation, autophagy, mitochondrial function, and angiogenesis in ectopic endom …
Through a combination of single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by TET3 overexpression (Toe-Macs) in three major human diseases associated …