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The role of IL-33/ST2 signaling in female reproductive diseases.

Female reproductive tissues repeatedly undergo controlled inflammation, immune adaptation, and tissue repair. Interleukin-33 (IL-33) and its receptor suppression of tumorigenicity 2 (ST2) sit at the center of these processes, but …

Published: June 12, 2026, midnight
p16 Beyond Senescence: Cancer Biology Lessons Applied to Endometriosis.

Endometriosis is an estrogen-dependent disease characterized by chronic inflammation and fibrosis and is a major cause of pelvic pain and infertility. Recent studies have reported dysregulated expression of p16INK4a, a …

Published: June 11, 2026, midnight
Thoracic Endometriosis and Catamenial Pneumothorax: Imaging Pitfalls and an Integrated Diagnostic Approach.

Catamenial pneumothorax is a rare form of recurrent spontaneous pneumothorax occurring in women in temporal association with the menstrual cycle, most commonly within 72 h before or after the onset …

Published: June 11, 2026, midnight
Deciphering immune-inflammatory dysregulation in the endometriotic microenvironment: insights from single-cell omics and artificial intelligence.

Endometriosis is a prevalent chronic inflammatory gynecological disorder affecting approximately 10% of reproductive-age women worldwide, characterized by endometrial-like tissue outside the uterine cavity. Ectopic lesion growth tracks closely with immune-inflammatory …

Published: June 11, 2026, midnight
Endometriosis-associated Pain: Mechanism, Neuroimmune Signature, and Translational Precision Strategies.

Endometriosis affects approximately 10% of reproductive-aged women worldwide and is a leading cause of chronic pelvic pain. Despite its high prevalence and substantial socioeconomic burden, the mechanisms underlying endometriosis-associated pain …

Published: June 10, 2026, midnight
Giant Cesarean Section Scar Endometriosis Presenting with Cyclic Pain: A Neglected Clinical Manifestation-A Case Report.

Endometriosis is a chronic gynecological disorder characterized by the presence of endometrium-like tissue outside the uterine cavity. It is most commonly found in the pelvic organs but may also occur …

Published: June 10, 2026, midnight
Squamous Cell Carcinoma Arising From Mature Cystic Teratoma in a 39-Year-Old Woman: A Case Report.

Ovarian carcinomas represent the second most common malignancy of the female genital tract; however, primary squamous cell carcinoma (SCC) is a rare subtype. Most of these tumors arise from malignant …

Published: June 10, 2026, midnight
FDG PET/CT in a Case of Clear Cell Carcinoma Arising From Abdominal Wall Endometriosis.

Abdominal wall endometriosis is rare. Malignant transformation of abdominal wall endometriosis is extremely rare. We describe FDG PET/CT findings in a case of clear cell carcinoma arising from abdominal wall …

Published: June 8, 2026, midnight
Breaking the endometriosis-stroke axis: lesion-focused hydrogel reprogramming of thromboinflammatory networks.

Endometriosis is a chronic, systemic inflammatory disorder characterized by the ectopic implantation of endometrial-like tissue and accompanied by persistent pain and infertility. Beyond the pelvis, accumulating epidemiological evidence indicates that …

Published: June 8, 2026, midnight
Anti-NRP1 peptide-engineered ROS/pH dual-responsive nanoparticles for Alpelisib delivery regulate Sema3A-NRP1/PI3K-AKT signaling to balance oxidative stress and inhibit angiogenesis in endometriosis.

Endometriosis progression is driven by oxidative stress and excessive angiogenesis within an inflammatory microenvironment. To overcome these challenges, we designed ROS/pH dual-responsive Alpelisib-loaded nanoparticles (Alp@TAT-AT7-NPs) functionalized with an anti-NRP1 peptide …

Published: June 6, 2026, midnight
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