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Mechanism of vascular endothelial growth factor regulating hypoxia and inflammatory microenvironment in endometriosis: based on bioinformatics and multi-level validation.

Endometriosis remains a prevalent gynecological disorder that affects women during their reproductive years, featured by progressive inflammation and enhanced HIF-1α expression. This paper intended to plumb the mechanism of vascular …

Published: Oct. 10, 2025, midnight
AntiCD44 antibody-conjugated gold nanoparticles for targeted photothermal therapy of endometriotic cells.

Endometriosis is a chronic gynecologic disease that needs newer and safer treatments. The proposed work aims to develop a nanosystem based on gold nanoparticles (AuNPs) to actively target human endometriosis …

Published: Aug. 13, 2025, midnight
PARP-2 acts on ILK signaling and pharmacological targeting of PARP-2 ameliorate endometriosis in a mouse model.

Endometriosis, an endocrine disorder in reproductive-aged women with an occurrence of ∼10 %, gives rise to inflammation, pelvic pain, menstrual irregularity, infertility, etc. One study demonstrated the elevated plasma level …

Published: Feb. 20, 2025, midnight
Peritoneal Endometriosis Impairs Ovarian Reserve and Increases Atresia in a Rat Model.

Background/Objectives: Endometriosis has a marked impact on fertility, although the mechanisms behind this relationship remain poorly understood, particularly in cases without significant anatomical distortions or in the context of ovarian …

Published: Feb. 3, 2025, midnight
Potential Modulatory Role of Phoenixin-14 in Epithelial-Mesenchymal Transition of Endometriotic 12Z Cells.

Background/Objectives: Endometriosis is a painful chronic condition in which the endometrium grows outside the uterus. The epithelial-mesenchymal transition (EMT) is critical to endometriosis progression, where cells lose epithelial traits and …

Published: Jan. 10, 2025, midnight
Expression of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) Gene and Its Regulation by miR200b in Ovarian Endometriosis.

Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have …

Published: Oct. 29, 2024, midnight
Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis.

This study investigated the correlation of Apolipoprotein-B mRNA-editing complex 3B (APOBEC3B) expression with hypoxia inducible factor 1α (HIF-1α), Kirsten rat sarcoma virus (KRAS) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) …

Published: Oct. 23, 2024, midnight
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