Latest Articles

Motor Factors Associated with Psychosocial Aspects in Women with Deep Endometriosis.

Deep endometriosis (DE) may be associated with chronic pelvic pain, pelvic floor dysfunction, sexual dysfunction, psychological distress, and impaired quality of life, though relationships remain poorly characterized. We investigated associations …

Single-Cell RNA Sequencing Reveals Immune Dysregulation and Candidate Drug Targets in Endometriosis.

Endometriosis is a chronic inflammatory disorder affecting 5-10% of women of reproductive age and is associated with chronic pain and infertility. While research has mainly focused on local lesions, systemic …

Ovarian Precancerous Lesions and Their Molecular Landscape: A Structured Scoping Review Focused on STIC and Related Precursors of Epithelial Ovarian Cancer.

Ovarian cancer remains one of the deadliest gynecologic malignancies because of late-stage diagnosis, biological heterogeneity, and the lack of effective early detection strategies. Epithelial ovarian cancer (EOC) comprises several histotypes, …

Chronic abdominal pain and dyspareunia in endometriosis: pain therapy with a nerve and muscle stimulation device with biofeedback function.

Endometriosis (EM) is frequently associated with chronic pelvic pain (CPP) and dyspareunia, often linked to secondary pelvic floor dysfunction and hypertonicity. To evaluate whether the use of an intravaginal electromyography …

Exploring the role of Brain-Derived Neurotrophic Factor as a biomarker in female infertility: A systematic review and meta-analysis.

Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival and development, and is also involved in oogenesis, follicle recruitment, and germ cell survival, which could impact reproduction. However, in humans, …

Functional outcomes after laparoscopic colorectal resection with natural orifice specimen extraction and conventional specimen extraction for deep endometriosis: a 24-month prospective cohort study.

To assess changes in bowel function, pain symptoms, and endometriosis-related quality of life over 24 months after laparoscopic colorectal resection with natural orifice specimen extraction (NOSE) and conventional abdominal specimen …

Editorial: The uterus immune microenvironment features in physiological and pathological conditions.

Transperineal Ultrasound in Chronic Pelvic Pain: A Systematic Review.

This systematic review aimed to explore the application and effectiveness of transperineal ultrasound as a diagnostic tool for evaluating pelvic floor musculature (PFM) dysfunction in patients with chronic pelvic pain …

Development and Preliminary Evaluation of the Pelvic Dysfunction Composite Score (PDCS): A Pilot Study in Women with Endometriosis.

Pelvic floor dysfunctions are common in women with endometriosis. Currently available assessment tools are limited to isolated domains that do not allow for a comprehensive multidimensional evaluation. This study aimed …

β-Glucuronidase at the gut-liver interface: Structural selectivity, enterohepatic reactivation, and the pharmacomicrobiomic case for precision inhibition.

β-Glucuronidase (β-G, EC 3.2.1.31) reverses phase II glucuronidation, and microbial β-G at the gut-liver interface reactivates biliary and circulating conjugates, closing enterohepatic loops for drugs, estrogens, bile acids, and bilirubin. …