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Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation.

Endometriosis is a painful gynecological inflammatory disease affecting up to 10% of females. When released by sensory neurons, calcitonin gene-related peptide (CGRP) shapes immunity, a process known as neuroimmune communication. …

Published: Oct. 21, 2025, midnight
Challenges in conducting a feasibility randomized controlled trial of medicinal cannabis for endometriosis pain in Australia.

People with endometriosis report consuming cannabis to manage their endometriosis symptoms, however, its efficacy has not been established in clinical studies. This study aimed to determine the feasibility, acceptability, and …

Published: Sept. 23, 2025, midnight
Efficacy of Elagolix and Relugolix for the Treatment of Pelvic Pain in Patients With Endometriosis: A Systematic Review.

Endometriosis is a chronic gynecological condition commonly associated with pelvic pain, dysmenorrhea, dyspareunia, and infertility. Owing to the limitations and adverse effects of traditional hormonal therapies, this study aimed to …

Published: Sept. 12, 2025, midnight
The endometriosis pain course: a randomized controlled trial of an internet-delivered psychological pain management program for endometriosis.

Limited research has examined psychological treatments for endometriosis-related chronic pain, despite its association with elevated disability, depression, and anxiety. Remotely delivered treatments have the potential to overcome barriers to access …

Published: Aug. 21, 2025, midnight
The vaginal microbiome drives endometriosis pain.

Despite being one of two cardinal disease symptoms, endometriosis pain is poorly understood. Using a validated mouse model, we demonstrate that endometriosis-associated vaginal dysbiosis is sufficient to induce pain in …

Published: Aug. 21, 2025, midnight
Factors Affecting Hormonal Therapy Ineffectiveness and Discontinuation due to Adverse Effects in Patients with Endometriosis-Associated Pain.

Endometriosis contributes to 5-21% of hospital admissions for pelvic pain. While hormonal therapies are pivotal in managing endometriosis-related pain, no single hormonal treatment suits all patients. We aimed to assess …

Published: Aug. 18, 2025, midnight
Exploring the Immune System's Role in Endometriosis: Insights Into Pathogenesis, Pain, and Treatment.

Endometriosis is a common gynecological condition that usually affects women during their reproductive years. The main goal of this narrative review is to understand the role of the innate and …

Published: July 1, 2025, midnight
Development of the COMPASS model of endometriosis: A COmprehensive model of pain encompassing agency, systemic factors and sense making.

Endometriosis is a chronic and progressive condition commonly associated with debilitating pain. Treatments for endometriosis pain are limited and usually invasive. Psychological interventions are a non-invasive intervention option and have …

Published: March 19, 2025, 12:13 a.m.
Does interdisciplinary group care for the treatment of endometriosis improve pain interference: protocol for a pilot randomised controlled trial at an urban academic medical centre.

Endometriosis affects 10-15% of people assigned female at birth and can cause chronic pelvic pain and impair many domains of quality of life, such as fertility, mood and bladder, bowel …

Published: March 5, 2025, midnight
Dietary Modification and Supplement Use For Endometriosis Pain.

Published: March 3, 2025, midnight
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