Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …
Background and Objectives: Endometriosis is a chronic, estrogen-dependent inflammatory disease with multifactorial pathogenesis. Increasing evidence suggests that alterations in the gut and reproductive tract microbiota may contribute to disease development, …
Estrogen receptor 1 (ESR1) and progesterone receptor (PGR) are essential regulators for endometrial receptivity and embryo implantation. Their expression is dysregulated in women with endometriosis-associated infertility. However, the relationship between …
Background: Predicting natural conception following surgical treatment remains a clinical challenge for endometriosis, a chronic inflammatory condition often associated with infertility. This study aimed to determine if simple, low-cost inflammatory …
Endometriosis is a chronic, debilitating condition characterized by heterogenous clinical manifestations. It has a prevalence of 5-10% in women of reproductive age, and 30-50% of individuals with endometriosis are affected …
The cervicovaginal microbiome-spanning from the vagina to endometrium-remains undercharacterized in endometriosis-associated infertility. Objective: To determine whether combined vaginal and cervical microbial profiles predict frozen embryo transfer (FET) outcomes.
To establish the cumulative pregnancy rate for the different therapeutic options usually offered to patients with bowel endometriosis-associated infertility.
Regulatory T-cells (Tregs) are central to peripheral immune tolerance and act as key players that sustain the immune homeostasis required for embryo receptivity, implantation, and placentation. Treg dysfunction accelerates inflammation, …
The management of infertility in women with bowel endometriosis remains a significant clinical challenge. The two primary therapeutic approaches include first-line medically assisted reproduction (MAR) and primary bowel surgery, with …