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Ovarian fibrosis as a common mechanism of infertility.

Female fertility has long been explained through observation of the ovarian follicle: the number of residing follicles and the quality of the oocyte. This review argues that the tissue surrounding …

Published: Sept. 24, 2026, midnight
NRF2 Signalling in Endometriosis: A Hormone-Independent Axis for Fertility-Preserving Therapeutic Innovation.

Endometriosis is a chronic inflammatory disease characterised by pain, infertility and recurrence. Current pharmacological management relies largely on hormonal suppression, which can reduce pain and disease activity but does not …

Published: Sept. 14, 2026, midnight
Modulating the Estrobolome and Inflammatory Microenvironment in Endometriosis: The Role of Microbiome-Targeted Interventions and Nutritional Compounds.

Endometriosis is a chronic estrogen-dependent systemic inflammatory disorder characterized by ectopic implantation of endometrial-like tissue, primarily on the ovaries, pelvic peritoneum, and bowel. According to the World Health Organization (WHO) …

Published: Sept. 3, 2026, midnight
A retrospective cohort study comparing controlled ovarian stimulation protocols for IVF/ICSI in women with endometriosis and diminished ovarian reserve.

Assisted reproductive treatment for women with endometriosis and diminished ovarian reserve (DOR) is challenging, and the optimal controlled ovarian stimulation (COS) protocol for this population remains uncertain. This study compared …

Published: Aug. 14, 2026, midnight
Superficial Peritoneal Endometriosis Beyond Surgical Diagnosis: A Narrative Review of Emerging Functional and Molecular Perspectives.

Background and Objectives: Superficial peritoneal endometriosis (SPE) remains one of the most difficult endometriosis phenotypes to diagnose non-invasively, because lesions are frequently small, multifocal, and poorly detectable using conventional imaging. …

Published: Aug. 2, 2026, midnight
Maximising and Maintaining Fertility in Suspected or Confirmed Endometriosis: A Structured Narrative Review for Clinical Practice.

Endometriosis affects a substantial proportion of women of reproductive age and is a common, often under-recognised contributor to subfertility. Its effects on fertility are multifactorial, and both the disease and …

Published: July 9, 2026, midnight
Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use.

Non-hormonal intrauterine devices (IUDs) create an inflammatory uterine environment while oral contraceptives (OC) suppress ovulation and have different associations with ovarian cancer risk. We have evaluated the associations of these …

Published: June 27, 2026, midnight
The Circadian-Light-Hygiene Hypothesis: A Potential Modulator of Fertility and Birthrate Trends.

Human fertility has declined sharply since 1950, and a growing body of evidence suggests that while conventional socioeconomic factors are well-established drivers of the broader demographic transition, they do not …

Published: June 26, 2026, midnight
Comparative analysis of natural versus ovarian stimulation cycles in intrauterine insemination by diverse infertility indications.

To describe clinical intrauterine insemination (IUI) outcomes among infertile patients with different infertility indications, and further compare reproductive outcomes between natural cycle (NC) and ovarian stimulation cycle (OSC) IUI.

Published: June 19, 2026, midnight
Validation of Endometriosis Fertility Index for the Prediction of Non-Assisted Reproductive Technology (ART) Pregnancy in Women With Endometriosis-Associated Infertility: A Prospective Cohort Study.

Introduction Endometriosis is a common cause of infertility and affects reproductive outcomes through multiple mechanisms, including pelvic adhesions, altered pelvic anatomy, and inflammatory changes. The Endometriosis Fertility Index (EFI) was …

Published: June 19, 2026, midnight
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