Latest Articles

Pathogenic Properties of Human Endometriotic Epithelial Cells Require Steroid Receptor Coactivator-2.

Commonly diagnosed in reproductive-age women, endometriosis is causally linked to subfertility, infertility, and chronic pelvic pain. Although theories exist on the etiopathogenesis of endometriosis, our understanding of its cellular and …

Opiranserin (VVZ-149): what's new in analgesics.

Opiranserin (VVZ-149) is a novel non-opioid, non-steroidal intravenous analgesic with triple antagonistic activity at glycine transporter 2 (GlyT2), purine 2 receptor 3 (P2X3), and serotonin receptor (5-HT2A). Its half-maximal inhibitory …

Sex-specific mechanisms of chronic pain.

For decades, we have known that women, especially younger women, are disproportionately affected by pain disorders, including irritable bowel syndrome, endometriosis, menstrual migraines, fibromyalgia, osteoarthritis, and neuropathic pain, all of …

Motor Factors Associated with Psychosocial Aspects in Women with Deep Endometriosis.

Deep endometriosis (DE) may be associated with chronic pelvic pain, pelvic floor dysfunction, sexual dysfunction, psychological distress, and impaired quality of life, though relationships remain poorly characterized. We investigated associations …

Transvaginal Ultrasound for Endometriosis: Learning From a Decade of Diagnostic Challenges Through a Retrospective Observational Cohort Study.

Endometriosis is a chronic, inflammatory condition associated with pelvic pain, subfertility, and reduced quality of life. Advances in enhanced transvaginal ultrasound (eTVUS), including systematic compartment-based scanning protocols and improved operator …

Robotic Excision of a Sciatic Nerve Schwannoma and Vascular Entrapment at the Greater Sciatic Foramen with Concomitant Deep Infiltrating Endometriosis Approach.

[A national questionnaire survey of the current status of diagnosis and treatment of endometriosis in China in 2024].

Objective: To investigate the current status of clinical practice and the implementation of existing guidelines for endometriosis in China, and to provide a reliable basis for relevant continuing medical education …

Use of symptom-reporting tools to support endometriosis identification and management in primary care: a realist synthesis.

Endometriosis affects 5-10% of women of reproductive age and is associated with chronic pain, infertility and reduced quality of life. Symptom Reporting Tools (SRTs) may support identification and management in …

Simvastatin and Primaquine Identified as Potential Endometriosis Therapeutics via a Novel Epithelial-Stromal Assembloid Drug Screening Assay.

Endometriosis is an estrogen-driven, inflammatory disorder affecting ~10% of menstruators, causing severe pain. Current treatments that reduce estrogen or inflammation have inconsistent efficacy and poor tolerability. Therapies identified via drug-repositioning …

Post-marketing safety profile of Myfembree in approved gynecologic indications: a disproportionality analysis based on the FAERS database.

Myfembree, a fixed-dose combination of relugolix, estradiol, and norethindrone acetate, is approved for premenopausal women with heavy menstrual bleeding associated with uterine fibroids and moderate to severe pain associated with …