To demonstrate the presence of peritoneal fluid (PF)-derived small extracellular vesicles (sEVs) in endometriosis and control samples, to characterise their protein content and to define endometriosis-specific biomarkers within the sEV …
Excessive activation of inflammatory responses and oxidative stress plays a critical role in the pathophysiology of endometriosis (EMs), which is characterized by ectopic lesion growth and chronic pelvic pain. However, …
Endometriosis is a multifaceted disease, causing debilitating pelvic pain in some patients, while being completely asymptomatic in others. The pathophysiology of endometriosis pain is not well understood and poorly correlated …
In this narrative review, we summarize current evidence regarding the endometrium undergoes cyclic remodeling driven by estrogen (E2) and progesterone (P4) signaling, with precise coordination essential for receptivity and pregnancy …
Endometriosis is a chronic inflammatory disease affecting approximately 10% of reproductive-age women. Immune dysregulation is central to its pathophysiology and interleukin-10 (IL-10) may contribute to immune tolerance, angiogenesis, and fibrosis.
Endometriosis is a chronic estrogen-dependent inflammatory disorder affecting approximately 10% of women of reproductive age. It remains a major contributor to chronic pelvic pain, infertility, and reduced quality of life. …
Endometriosis (EMs) is a widespread gynecological disease, affecting approximately 6-10% of females of child-bearing age. Despite its significant influence on women's health, the specific pathophysiology remains unclear. The enrichment of …
A broad range of genetic and epigenetic factors contributes to female infertility, a substantial proportion of which is related to ovulatory disorders. Any factor that disrupts the normal function of …
Endometriosis was once thought to affect only reproductive-aged women. However, 2-5% of postmenopausal individuals remain affected. Guidance for this group is limited. This review outlines an updated approach to postmenopausal …
Background: This review aims to systematically summarize the lineage origins, subtype classification, and functional dynamics of endometrial macrophages, clarify their mechanisms of action in normal reproductive physiology (menstrual cycle, pregnancy) …