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A Machine Learning-Based Prediction Model for Deep Infiltrating Endometriosis.

Deep infiltrating endometriosis (DIE) is a severe endometriosis phenotype. This study aimed to develop and internally validate a machine learning-based predictive model for DIE using retrospective clinical data from a …

Published: Oct. 1, 2026, midnight
A Phase 2a/b, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Efficacy and Safety of Linustedastat (OG-6219) in Women with Moderate to Severe Endometriosis-Related Pain.

Endometriosis causes pelvic pain, dysmenorrhea (DYS), dyspareunia, and fertility issues. Linustedastat (OG-6219) is an oral, selective inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (HSD17β1), an enzyme involved in local estradiol biosynthesis. …

Published: Sept. 9, 2026, midnight
Endometriosis Longitudinal Fertility Study (ELFS): a prospective longitudinal cohort study of the effect of conservative and surgical management for moderate to severe endometriosis on future fertility - study protocol.

Endometriosis is associated with reduced pregnancy and live birth rates in patients attempting both spontaneous and assisted conception. At present, it is unclear whether prepregnancy surgery for moderate or severe …

Published: Aug. 20, 2026, midnight
Endometriosis Unveiled: A Tale of Two Extremes, From Acute Sepsis to Silent Suspicion.

Endometriosis may rarely present with atypical manifestations that closely mimic intra-abdominal malignancy or severe pelvic sepsis, resulting in significant diagnostic uncertainty. We present two contrasting cases of presumed severe endometriosis …

Published: July 18, 2026, midnight
Posterior Uterine Rupture during Pregnancy in a Patient with Previous Surgery for Severe Endometriosis: A Case Report.

Deep infiltrating endometriosis (DIE) is a severe pathology requiring complex pelvic surgery, which carries a rare but serious risk of uterine rupture during pregnancy. We report a primiparous patient who …

Published: June 30, 2026, midnight
Surgically confirmed severe endometriosis is associated with lower risk of steatotic liver disease: Evidence of estrogen-linked hepatic-reproductive crosstalk.

The prevalence of steatotic liver disease (SLD) is increasing globally. Endometriosis, affecting up to 10% of women, is a major cause of infertility. While associations between endometriosis and metabolic syndrome …

Published: June 6, 2026, midnight
Serum biomarkers associated with disease stage and pain severity among women with endometriosis in Indonesia.

Endometriosis is a chronic estrogen-dependent disease characterized by the presence of endometrial-like tissue outside the uterine cavity, resulting in chronic inflammation, recurrent pain, and infertility, and affecting approximately 190 million …

Published: May 21, 2026, midnight
Efficacy and Safety of Elagolix Versus Dienogest for Treatment of Moderate-to-Severe Endometriosis Pain: A Phase III, Multicentric, Double-Blind, Active-Controlled, Non-Inferiority Study.

To compare the efficacy, safety and tolerability of elagolix with dienogest in women with moderate-to-severe endometriosis-associated pain.

Published: May 11, 2026, midnight
Laparoscopic Retrograde Hysterectomy: A Review of Techniques, Indications, and Outcomes.

Laparoscopic retrograde hysterectomy (LRH) represents an innovative minimally invasive approach for managing complex pelvic pathology where conventional techniques are contraindicated. This review synthesizes current evidence regarding its techniques, indications, and …

Published: March 18, 2026, midnight
Reply to comment on "Severe endometriosis complicated by deep vein thrombosis and pulmonary embolism in the absence of hormone therapy: A case report and literature review".

Published: March 13, 2026, midnight
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