This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple-lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an …
Endometriosis (ENDO) is an estrogen-dependent chronic gynaecological manifestation of uterine fragments attached outside of the uterus, accompanied by debilitating chronic pelvic pain. The evoked assays often employed fail to capture …
Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We …
Visceral pain and migraine, especially at a high frequency/chronic, are frequent comorbidities, but little is known about their mutual influences. This study investigated if visceral pain-migraine comorbidity involves higher migraine …
Endometriosis (ENDO), a chronic inflammatory disease affecting approximately 190 million women globally, is characterized by fibrosis, a feature often challenging to replicate in murine models. To identify an optimal syngeneic …
Cyclic and noncyclic chronic pelvic pain (CPP) represent a major problem for both affected patients and healthcare providers due to its effects on physical and mental health. In times of …
Endometriosis, a persistent inflammatory disease, is associated with pelvic or abdominal pain. The immune system and sensory nervous system show a synergistic effect on regulation of pain. In particular, Interleukin-33 …
Endometriosis is a highly prevalent gynecological disease characterized by the presence of endometrium-like tissue outside the uterus, whose etiopathology is far from being elucidated. The most frequent complains of patients …
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women and transgender men. Current treatments are ineffective for a substantial proportion of patients, underscoring the …