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Endometriosis, subclinical cardiac remodeling, and cardiovascular risk: mechanistic insights from cardiac magnetic resonance and mediation analysis.

Endometriosis is a systemic gynecological disorder affecting ~ 10% of reproductive-aged women and shares pathophysiological features with cardiovascular disease (CVD). However, its associations with cardiac remodeling and CVD risk, as …

Published: May 2, 2026, midnight
Obstructive Sleep Apnea and Female Reproductive Endocrine Diseases: A Mendelian Randomization and Mediation Analysis.

This study aimed to evaluate the potential causal association between obstructive sleep apnea (OSA) and the risk of female reproductive endocrine diseases (REDs), including polycystic ovary syndrome (PCOS), endometriosis (EMs), …

Published: April 16, 2026, midnight
Effects of endocrine disrupting chemicals and plasma metabolome on female reproductive diseases: A multidimensional Mendelian randomization study.

Endocrine disrupting chemicals (EDCs) have been associated with disorders affecting female reproductive health, although the precise causal connections and underlying pathways between these substances and such disorders remain incompletely elucidated. …

Published: Jan. 22, 2026, midnight
Risk of postpartum depression among women with endometriosis: the Norwegian mother, father and child cohort study (MoBa).

Women with endometriosis have a higher burden of anxiety and depression. Whether they are at increased risk of postpartum depression (PPD) remains unclear. We aimed to compare the risk of …

Published: Jan. 12, 2026, midnight
The effect of infertility-related stress on fertility-related quality of life in reproductive-age married women with endometriosis: the mediating role of family resilience.

This study investigated fertility-related quality of life among married women of reproductive age (20-45 years) with endometriosis-associated infertility, focusing on the mediating role of family resilience between infertility-related stress and …

Published: Nov. 16, 2025, midnight
Impact of the lipid-inflammation axis on endometriosis risk: a multicenter case-control study using mediation analysis.

Endometriosis (EM) is often accompanied by dyslipidemia, but the causal relationship between dyslipidemia and inflammation remains unclear. This study aimed to explore the association between the lipid-inflammation axis and EM …

Published: Nov. 13, 2025, midnight
Role of HLA-DRA-CREB3L4 regulatory axis in the pathogenesis of ovarian endometriosis: Inhibition of CREB3L4 expression by HLA-DRA increases the risk of disease.

Ovarian endometriosis is a common gynecological condition characterized by the abnormal growth of endometrial-like tissue in locations outside the uterus, and its development remains poorly understood. This study aims to …

Published: Nov. 11, 2025, midnight
Impact of the Lipid–Inflammation Axis on Endometriosis Risk: A Multicenter Case–Control Study Using Mediation Analysis - Frontiers

Impact of the Lipid–Inflammation Axis on Endometriosis Risk: A Multicenter Case–Control Study Using Mediation Analysis Frontiers

Published: Oct. 28, 2025, 9:44 p.m.
The effect of phytoestrogens and PAHs on endometriosis and the involvement of gut microbiota, inflammation, and molecular targets.

Endometriosis is a common estrogen-dependent inflammatory disease, yet its complex etiology is not fully understood. Endocrine Disrupting Chemicals (EDCs) exposure disrupts human reproduction, but studies on mixed EDCs and endometriosis …

Published: Oct. 15, 2025, midnight
Effect of education on endometriosis and mediating effects: a mendelian randomization study.

To assess the potential impact of years of education, which serves as a measure of socioeconomic inequality, on the occurrence of endometriosis, and to quantify the potential influence of modifiable …

Published: Aug. 8, 2025, midnight
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