Endometriosis is a prevalent gynecologic disorder that significantly impacts women's health. However, its underlying pathogenesis remains unknown. This study aimed to ascertain causal associations between plasma protein levels and endometriosis …
There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease-associated plasma proteins with causal genetic evidence provides an opportunity to identify new …
Endometriosis is a chronic, estrogen-dependent inflammatory disorder that causes substantial pain and infertility. Observational studies have reported higher rates of multiple psychiatric disorders among individuals with endometriosis; however, confounding and …
Deep infiltrating endometriosis (DIE) is a highly fibrotic and deeply invasive subtype of endometriosis that causes severe pelvic pain, infertility and marked impairment of quality of life. Metabolic, microbial and …
Endometriosis is a chronic estrogen-dependent inflammatory disease that shares epidemiological and pathological features with endometrial cancer. However, the cellular and genetic mechanisms underlying this association remain unclear.
The comorbidity between endometriosis and migraine has long been recognized clinically, yet a unifying pathophysiological explanation has remained elusive. Traditional models, centered on hormonal fluctuations or secondary inflammation are lacking …
The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disentangle …
The potential bidirectional causal relationship between endometriosis and serum 25-hydroxyvitamin D has been previously investigated. Nevertheless, the results could be impacted by confounding factors and reverse causality because of the …
Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to …
Endometriosis is a complex gynaecological disorder that affects 10%-15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in endometriosis pathogenesis, …