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Single-cell and spatially resolved omics reveal transcriptional and metabolic signatures of ovarian endometriomas.

Endometriosis involves ectopic growth of endometrial-like tissue, yet the spatial transcriptomic and metabolic landscape of ovarian endometriomas remains poorly understood. This investigation presents a comprehensive multi-omics analysis of ovarian endometriomas …

Published: Nov. 22, 2025, midnight
Metabolome analysis as a potential source of endometriosis biomarkers with the use of multiomics approach in its diagnosis.

Endometriosis poses diagnostic challenges. This study aimed to analyze the metabolomic profiles of plasma and peritoneal fluid samples obtained from women with endometriosis compared to controls. Our multicenter study involved …

Published: Nov. 5, 2025, midnight
Nanodrug impact on female reproductive health and fetal development: From translation approaches to long-term safety concern.

Biomaterials for drug delivery offer significant advantages over conventional medications, including enhanced cellular uptake, improved drug stability, targeted delivery, and controlled drug release. Cutting-edge nanodrugs delivery approaches such as drugs …

Published: Nov. 5, 2025, midnight
Identification of metabolic reprogramming-associated biomarkers in endometriosis through integrated bioinformatics analysis.

Endometriosis (EMs), a common gynecological disorder, involves complex molecular mechanisms. Metabolic reprogramming (MR) has been recognized as a hallmark of EMs, contributing to lesion survival and immune microenvironment remodeling. This …

Published: Oct. 30, 2025, midnight
Integrative microbiome-metabolomics identifies Pseudomonas as a potential pathogenic factor in endometriosis.

Endometriosis (EMS) is a chronic disease characterized by unclear etiology, influenced by various genetic and environmental factors, with no definitive biomarkers available for early screening. Recent studies suggest that the …

Published: Oct. 30, 2025, midnight
Mechanism of action of HuPoSan on EMs rats as revealed by multi-omics combined with network pharmacology - ScienceDirect.com

Mechanism of action of HuPoSan on EMs rats as revealed by multi-omics combined with network pharmacology ScienceDirect.com

Published: Oct. 27, 2025, 6 a.m.
Mechanism of action of HuPoSan on EMs rats as revealed by multi-omics combined with network pharmacology.

Endometriosis (EMs) is a persistent inflammatory condition whose three main symptoms, mass, pain, and infertility, severely affect female patients of childbearing age. Hu-Po-San (HPS), a preparation consisting of various herbal …

Published: Oct. 26, 2025, midnight
Advances in Endometrial Cancer Biomarkers via Multi-Omics - Bioengineer.org

Advances in Endometrial Cancer Biomarkers via Multi-Omics Bioengineer.org

Published: Oct. 20, 2025, 6:54 a.m.
Fibroblast heterogeneity and FN1-mediated signaling in endometriosis revealed by single-cell and spatial transcriptomics.

Endometriosis (EM) is a chronic gynecological disorder that affects 5% to 10% of women of childbearing age, often causing pelvic pain and infertility. Fibrosis is a hallmark of EM progression, …

Published: Oct. 13, 2025, midnight
Plant-based bioactives and oxidative stress in reproduction: anti-inflammatory and metabolic protection mechanisms.

Oxidative stress plays a central role in reproductive disorders, with food bioactive compounds offering therapeutic potential through their antioxidant properties. This review examines antioxidant active ingredients from plant-based foods and …

Published: Oct. 9, 2025, midnight
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