This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple-lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an …
Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP in endometriosis.
Pain is the primary symptom of endometriosis and may progress into a chronic, acyclic condition driven by neuroinflammatory mechanisms, leading to neuropathic and ultimately nociplastic pain. Central sensitization, a form …
Endometriosis is a heterogeneous pain condition with variable symptom expression. Abuse history has been associated with amplified pain, gastrointestinal symptoms, and central sensitization in varying populations; however, whether these effects …
To determine the impact of a Chronic Pelvic Pain (CPP) Toolkit on patient satisfaction.
This study sought to assess the impact of transcutaneous electrical nerve stimulation (TENS) prescribed by gynecologists in routine practice on pain, pelvic sensitization, quality of life, and catastrophization scores in …
Pain in endometriosis involves not only nociceptive but also neuropathic and neurogenic components, reflecting its complex nature. Histamine, a biogenic amine, has emerged as a critical mediator connecting inflammation and …
To assess whether higher baseline Central Sensitization Inventory (CSI) scores are linked to quality-of-life outcomes and patient's impression of improvement after surgery for chronic pelvic pain.
Endometriosis is a chronic, inflammatory disease with considerable symptom load in affected female patients. Cyclic pain (associated with menstruation) dominates in most patients, but few patients suffer from persistent non-cyclic …
Chronic pain is a widespread condition affecting millions globally, placing significant strain on healthcare systems, as evidenced by the current opioid crisis. Despite advances in pain management, conventional treatments often …