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Preliminary Evaluation of Leuprorelin Acetate Microspheres Plus Levonorgestrel-Releasing Intrauterine System in Endometriosis: An Exploratory Study Focusing on BNIP3 and EPAC1 Expression.

This exploratory pilot study aimed to assess the preliminary clinical effects of leuprorelin acetate microspheres for injection [gonadotropin-releasing hormone agonist (GnRH-a)] combined with levonorgestrel-releasing intrauterine system (LNG-IUS) in treating endometriosis …

Published: May 14, 2026, midnight
The impact of different energy sources on redox balance during endometriotic cyst laparoscopy.

The aim of the study was to follow the impact of cystectomy and compare bipolar and laser electrocoagulation on prooxidative stress biomarkers and antioxidative capacity. A total of 60 women …

Published: May 14, 2026, midnight
Sedentary behavior, physical activity, psychological well-being, and gynecologic and obstetric disorders: A multivariable Mendelian randomization and mediation analysis.

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disentangle …

Published: May 13, 2026, midnight
Dopamine D2 Receptor Agonists as Modulators of VEGF-A-Driven Angiogenesis: Mechanisms, Clinical Evidence, and Translational Opportunities.

Angiogenesis mediated by vascular endothelial growth factor A (VEGF-A) is essential for physiological vascular remodeling but also drives pathological processes, including tumor growth, ocular neovascularization, and inflammation. Emerging evidence has …

Published: May 13, 2026, midnight
Causal effects of endometriosis on serum 25-hydroxyvitamin D: Evidence from Mendelian randomization study.

The potential bidirectional causal relationship between endometriosis and serum 25-hydroxyvitamin D has been previously investigated. Nevertheless, the results could be impacted by confounding factors and reverse causality because of the …

Published: May 13, 2026, midnight
Safety and efficacy of retromuscular-onlay dual-mesh reconstruction for massive abdominal wall defects secondary to abdominal wall endometriosis resection.

Massive abdominal wall defects resulting from radical abdominal wall endometriosis (AWE) resection present a major reconstructive challenge. This study aims to assess feasibility and short-term safety of a standardized retromuscular-onlay …

Published: May 13, 2026, midnight
Adoption of robot-assisted surgery for hysterectomy in France: a nationwide analysis of surgical routes and length of hospital stay (2020-2024).

Robot-assisted hysterectomy (RAH) has been progressively introduced in gynecologic surgery, yet nationwide data describing its uptake and early efficiency outcomes remain limited. We described trends in surgical route for hysterectomy …

Published: May 13, 2026, midnight
TMEM16A chloride channels in the female reproductive tract and their role in normal and dysfunctional pregnancy and labour.

Female fertility relies heavily on the health of the oviduct and uterus. Each of these organs consist of a muscular tube lined by epithelial cells. In this review, we discuss …

Published: May 13, 2026, midnight
Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies.

Ovarian cancer (OC) remains a major global health issue, often diagnosed late and lacking effective screening.

Published: May 13, 2026, midnight
The role of the SIRT1/FOXO1 axis in regulating autophagy and inflammation in endometriosis.

Endometriosis, a common chronic gynecological disorder, involves cellular autophagy and inflammatory processes in its pathogenesis. However, the specific regulatory mechanisms of autophagy and inflammation in endometriosis remain unknown. In this …

Published: May 13, 2026, midnight
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